C57BL/6JCya-BC048562em1flox/Cya
Common Name:
BC048562-flox
Product ID:
S-CKO-11301
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
BC048562-flox
Strain ID
CKOCMP-434439-BC048562-B6J-VA
Gene Name
Product ID
S-CKO-11301
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-BC048562em1flox/Cya mice (Catalog S-CKO-11301) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000057265
NCBI RefSeq
NM_001004192
Target Region
Exon 4
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
BC048562 is a gene whose function was previously less well-known. From the study, it was part of a set of genes investigated in single-gene knockout mouse models to explore genetic determinants of pain [1].
In a large-scale gene-targeted screen, 110 single-gene knockout mouse strains were tested for nociception and hypersensitivity assays. Among the 13 single-gene knockout strains with altered nocifensive behavior, BC048562 was identified. This indicates that the knockout of BC048562 leads to changes in nocifensive behavior, suggesting its involvement in nociception pathways [1].
In conclusion, BC048562 plays a role in nociception as revealed by gene-knockout mouse models. These models have provided new knowledge about the genetic mechanisms of inflammatory pain, suggesting that BC048562 could potentially be a target for further research in understanding and treating pain-related conditions [1].
References：
1. Wotton, Janine M, Peterson, Emma, Flenniken, Ann M, Mandillo, Silvia, White, Jacqueline K. 2021. Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen. In Pain, 163, 1139-1157. doi:10.1097/j.pain.0000000000002481. https://pubmed.ncbi.nlm.nih.gov/35552317/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen