Hnrnpa2b1, or heterogeneous nuclear ribonucleoprotein A2/B1, is an N6-methyladenosine (m6A) reader that binds to nascent RNA, playing a crucial role in various RNA metabolism processes. It is involved in pathways like innate immune response, cell proliferation, and stress granule regulation, thus having significant biological importance. Genetic models, such as KO mouse models, are valuable for studying its functions [1,2,3].

Knockout of Hnrnpa2b1 in mice leads to Sertoli cell-only syndrome (SCOS), causing complete male infertility, revealing its essential role in male mouse fertility [2]. In multiple myeloma, depletion of HNRNPA2B1 in MM cells inhibits cell proliferation and induces apoptosis, suggesting its promoting role in the progression of this cancer [1]. In hepatocellular carcinoma, knockout of hnRNPA2B1 reduces cell proliferation, migration, and invasion in vitro and inhibits tumor formation in graft experiments, indicating its contribution to tumorigenesis and progression of HCC [4].

In conclusion, Hnrnpa2b1 is essential in processes like male fertility and cancer progression. The KO mouse models have significantly contributed to understanding its role in male infertility and cancer-related disease areas, highlighting its potential as a therapeutic target in cancer treatment.