C57BL/6JCya-Zfp326em1flox/Cya
Common Name:
Zfp326-flox
Product ID:
S-CKO-11730
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Zfp326-flox
Strain ID
CKOCMP-54367-Zfp326-B6J-VA
Gene Name
Product ID
S-CKO-11730
Gene Alias
5730470H14Rik; ZAN75; Znf326
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp326em1flox/Cya mice (Catalog S-CKO-11730) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000031227
NCBI RefSeq
NM_018759
Target Region
Exon 5
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Zfp326, also known as zinc finger protein 326, is a gene whose functions seem to be related to multiple biological processes. It contains zinc-finger motifs and may function as a transcriptional regulator [4,5]. It has been implicated in pathways related to neurodegeneration and antidepressant treatment response [1,2].
In the context of neurodegeneration, lncRNA NR_030777 alleviates paraquat-induced neurotoxicity by regulating Zfp326, suggesting Zfp326 is involved in paraquat-induced neurodegenerative disorders like Parkinson's disease (PD) [1,3]. In studies related to antidepressant treatment, the mouse Zfp326 gene shows a linkage signal related to the anti-immobility effect of fluoxetine in the forced swim test, and its human homologue ZNF326 has SNPs associated with antidepressant treatment response in major depressive disorder patients [2].
In conclusion, Zfp326 plays important roles in neurodegeneration-related processes and antidepressant treatment response. Studies, especially those using mouse models, have revealed its involvement in these biological functions, providing insights into potential mechanisms underlying PD and antidepressant treatment, which may contribute to the development of new treatment strategies for these diseases.
References：
1. Yang, Hongyu, Lin, Qingxia, Chen, Nengzhou, Wang, Yuan-Liang, Li, Huangyuan. . LncRNA NR_030777 Alleviates Paraquat-Induced Neurotoxicity by Regulating Zfp326 and Cpne5. In Toxicological sciences : an official journal of the Society of Toxicology, 178, 173-188. doi:10.1093/toxsci/kfaa121. https://pubmed.ncbi.nlm.nih.gov/32735315/
2. Liou, Ying-Jay, Chen, Chien-Hsiun, Cheng, Chih-Ya, Tsai, Shih-Jen, Hong, Chen-Jee. 2012. Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response. In PloS one, 7, e32984. doi:10.1371/journal.pone.0032984. https://pubmed.ncbi.nlm.nih.gov/22666313/
3. Wang, Lijin, Yang, Hongyu, Wang, Qingqing, Wu, Siying, Li, Huangyuan. 2018. Paraquat and MPTP induce alteration in the expression profile of long noncoding RNAs in the substantia nigra of mice: Role of the transcription factor Nrf2. In Toxicology letters, 291, 11-28. doi:10.1016/j.toxlet.2018.04.002. https://pubmed.ncbi.nlm.nih.gov/29627306/
4. Lee, J Y, Kambe, M, Hayashi, M, Takenaga, K. . Cloning and characterization of a novel zinc finger protein that associates with nuclear matrix. In DNA and cell biology, 17, 849-58. doi:. https://pubmed.ncbi.nlm.nih.gov/9809746/
5. Lee, J Y, Nakane, Y, Koshikawa, N, Hayashi, M, Takenaga, K. . Characterization of a zinc finger protein ZAN75: nuclear localization signal, transcriptional activator activity, and expression during neuronal differentiation of P19 cells. In DNA and cell biology, 19, 227-34. doi:. https://pubmed.ncbi.nlm.nih.gov/10798446/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen