C57BL/6NCya-Trpv4em1flox/Cya
Common Name
Trpv4-flox
Product ID
S-CKO-12700
Backgroud
C57BL/6NCya
Strain ID
CKOCMP-63873-Trpv4-B6N-VA
When using this mouse strain in a publication, please cite “Trpv4-flox Mouse (Catalog S-CKO-12700) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Trpv4-flox
Strain ID
CKOCMP-63873-Trpv4-B6N-VA
Gene Name
Product ID
S-CKO-12700
Gene Alias
0610033B08Rik, OTRPC4, Trp12, VR-OAC, VRL-2, VROAC
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000071968
NCBI RefSeq
NM_022017
Target Region
Exon 4~6
Size of Effective Region
~2.4 kb
Overview of Gene Research
TRPV4, short for transient receptor potential channel subfamily V member 4, is a polymodal, nonselective, calcium-permeant cation channel. It is activated by both endogenous and exogenous stimuli, participating in numerous physiological and pathophysiological processes. TRPV4-expressing cells include both neuronal and non-neuronal ones, responding to various biochemical and biomechanical stimuli [1,2].
In macrophages, TRPV4 plays a crucial role in multiple inflammatory conditions. Deletion of TRPV4 in macrophages suppresses allergic and non-allergic itch in a mouse model, suggesting its role in skin disease [1]. In sepsis-induced lung injury, TRPV4-knockout in macrophages impacts glucose uptake through GLUT1, phagolysosome maturation, and ultimately limits sepsis-induced lung injury [3].
In conclusion, TRPV4 is essential in various biological processes, especially in the context of inflammation and immunity. The use of TRPV4-knockout mouse models has revealed its role in diseases such as skin diseases and sepsis-induced lung injury, providing valuable insights into the mechanisms underlying these diseases and potential therapeutic targets.
References：
1. Dutta, Bidisha, Arya, Rakesh K, Goswami, Rishov, Sharma, Shweta, Rahaman, Shaik O. 2019. Role of macrophage TRPV4 in inflammation. In Laboratory investigation; a journal of technical methods and pathology, 100, 178-185. doi:10.1038/s41374-019-0334-6. https://pubmed.ncbi.nlm.nih.gov/31645630/
2. Grace, Megan S, Bonvini, Sara J, Belvisi, Maria G, McIntyre, Peter. 2017. Modulation of the TRPV4 ion channel as a therapeutic target for disease. In Pharmacology & therapeutics, 177, 9-22. doi:10.1016/j.pharmthera.2017.02.019. https://pubmed.ncbi.nlm.nih.gov/28202366/
3. Orsini, Erica M, Roychowdhury, Sanjoy, Gangadhariah, Mahesha, Vachharajani, Vidula, Scheraga, Rachel G. . TRPV4 Regulates the Macrophage Metabolic Response to Limit Sepsis-induced Lung Injury. In American journal of respiratory cell and molecular biology, 70, 457-467. doi:10.1165/rcmb.2023-0456OC. https://pubmed.ncbi.nlm.nih.gov/38346220/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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