C57BL/6JCya-Pigbos1em1flox/Cya
Common Name
Pigbos1-flox
Product ID
S-CKO-13036
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-66364-Pigbos1-B6J-VA
When using this mouse strain in a publication, please cite “Pigbos1-flox Mouse (Catalog S-CKO-13036) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pigbos1-flox
Strain ID
CKOCMP-66364-Pigbos1-B6J-VA
Gene Name
Product ID
S-CKO-13036
Gene Alias
2310009A05Rik, 5031420N21Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000184126
NCBI RefSeq
NM_001308425
Target Region
Exon 2
Size of Effective Region
~0.6 kb
Overview of Gene Research
Pigbos1 is a gene with its function related to the outcome prediction of cutaneous melanoma. Although no key aliases are provided, in the context of cutaneous melanoma research, it is part of a six-lncRNA signature, which can classify patients into high-risk and low-risk groups according to survival time [1].
In the study of cutaneous melanoma, a set of six lncRNAs including Pigbos1 was identified. A linear combination of these six lncRNAs was constructed as a signature. This signature was able to classify patients in the training cohort into different risk groups with significantly different survival times. Its prognostic value was further validated in both the validation cohort and the entire TCGA cohort [1].
In conclusion, Pigbos1, as part of a six-lncRNA signature, has potential value in predicting the prognosis of cutaneous melanoma patients. The study of this gene in the context of cutaneous melanoma helps to better understand the molecular heterogeneity of the disease and may provide new perspectives for its prognosis assessment and treatment.
References：
1. Ma, Xu, He, Zhijuan, Li, Ling, Yang, Daping, Liu, Guofeng. 2017. Expression profiles analysis of long non-coding RNAs identified novel lncRNA biomarkers with predictive value in outcome of cutaneous melanoma. In Oncotarget, 8, 77761-77770. doi:10.18632/oncotarget.20780. https://pubmed.ncbi.nlm.nih.gov/29100423/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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