C57BL/6JCya-Tnfaip8l1em1flox/Cya
Common Name:
Tnfaip8l1-flox
Product ID:
S-CKO-13088
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tnfaip8l1-flox
Strain ID
CKOCMP-66443-Tnfaip8l1-B6J-VA
Gene Name
Product ID
S-CKO-13088
Gene Alias
2600017J23Rik; TIPE1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
17
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tnfaip8l1em1flox/Cya mice (Catalog S-CKO-13088) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000077788
NCBI RefSeq
NM_025566
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Tnfaip8l1, also known as TIPE1, is a member of the TNFAIP8 family. It plays important roles in multiple biological processes, including tumorigenesis, immune response regulation, and autophagy [1,4,5,6]. It is involved in pathways such as the PI3K-Akt and mTOR pathways [5]. Genetic models are valuable for studying its functions.
In a study on diabetic nephropathy, conditional knockout of Tipe1 in renal tubular epithelial cells (RTECs) decreased urine protein creatinine ratio, renal tubular damage, and interstitial fibrosis in STZ-induced mice, indicating its role in the progression of this disease [2]. In a Parkinson's disease model, Tnfaip8l1/Oxi-β was upregulated by oxidative stress, bound to FBXW5, increased TSC2 stability, decreased mTOR phosphorylation, and enhanced autophagy [3].
In conclusion, Tnfaip8l1 has diverse functions in disease processes like diabetic nephropathy and Parkinson's disease. Studies using gene knockout models have revealed its role in these conditions, which contributes to our understanding of the underlying mechanisms and may provide potential therapeutic targets [2,3].
References：
1. Sun, Jinghui, Zhang, Xuezhong, Zhu, Bin, Chen, Yingjun, Wang, Hui. . A pan-cancer analysis of TNFAIP8L1 in human tumors. In Medicine, 102, e36291. doi:10.1097/MD.0000000000036291. https://pubmed.ncbi.nlm.nih.gov/38065896/
2. Liu, Lei, Bai, Fang, Song, Hui, Yang, Xiangdong, Liang, Xiaohong. 2022. Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy. In Redox biology, 50, 102260. doi:10.1016/j.redox.2022.102260. https://pubmed.ncbi.nlm.nih.gov/35152003/
3. Ha, Ji-Young, Kim, Ji-Soo, Kang, Young-Hee, Kim, Yoon-Seong, Son, Jin H. 2013. Tnfaip8l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. In Journal of neurochemistry, , . doi:10.1111/j.1471-4159.2013.12643.x. https://pubmed.ncbi.nlm.nih.gov/24372178/
4. Gao, Jie, Zhang, Hanting, Zhang, Fang. 2023. Research progress of TIPE2 in immune-related diseases. In International immunopharmacology, 121, 110514. doi:10.1016/j.intimp.2023.110514. https://pubmed.ncbi.nlm.nih.gov/37348234/
5. Goldsmith, Jason R, Fayngerts, Svetlana, Chen, Youhai H. 2017. Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins. In Cellular & molecular immunology, 14, 482-487. doi:10.1038/cmi.2017.4. https://pubmed.ncbi.nlm.nih.gov/28287114/
6. Bordoloi, Devivasha, Banik, Kishore, Shabnam, Bano, Sethi, Gautam, Kunnumakkara, Ajaikumar B. 2018. TIPE Family of Proteins and Its Implications in Different Chronic Diseases. In International journal of molecular sciences, 19, . doi:10.3390/ijms19102974. https://pubmed.ncbi.nlm.nih.gov/30274259/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen