C57BL/6JCya-Oip5os1em1flox/Cya
Common Name:
Oip5os1-flox
Product ID:
S-CKO-13184
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Oip5os1-flox
Strain ID
CKOCMP-66602-Oip5os1-B6J-VA
Gene Name
Product ID
S-CKO-13184
Gene Alias
1190006L01Rik; 1700020I14Rik; 4933437I03Rik; Cyrano; Oip5as1; linc-oip5
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Oip5os1em1flox/Cya mice (Catalog S-CKO-13184) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000147425
NCBI RefSeq
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Target Region
Exon 3
Size of Effective Region
~4.3 kb
Detailed Document
Overview of Gene Research
Oip5os1, also known as 1700020I14Rik, OIP5-AS1, and Cyrano, is a long non-coding RNA (lncRNA) [4]. It is broadly expressed across multiple tissues, with significant enrichment in the nervous system, skeletal muscle, and striated muscles [4]. It has regulatory functions in normal cellular processes such as cell proliferation and survival [4].
In male mice with diabetes, deletion of Oip5os1 leads to left atrial dysfunction, myopathy, anesthesia intolerance, and premature death. This is associated with a reduction in the metabolic regulator ERRalpha and a trend for a reduction in Serca2a in the atria of knockout (KO) mice compared to wild-type (WT) mice [1]. In chronic unpredictable mild stress-induced mice, Oip5os1 is involved in the circ_0008405/miR-25-3p/Gata2 network, and geniposide can regulate this network to alleviate depression-like behaviors [2]. In pre-eclampsia (PE), PFOS exposure downregulates Oip5os1, and through the Oip5os1/miR-155/Rnd3 axis, it impairs trophoblast proliferation and migration [3].
In conclusion, Oip5os1 plays important roles in normal cellular processes and is involved in various disease conditions such as diabetes-related atrial dysfunction, depression-like behaviors, and PE. The KO mouse models in these studies have been crucial in revealing the functions of Oip5os1 in these specific biological processes and disease states, providing insights into potential therapeutic targets. [1-3].
References:
1. Zhuang, Aowen, Tan, Yanie, Liu, Yingying, Calkin, Anna C, Drew, Brian G. . Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes. In Physiological reports, 11, e15869. doi:10.14814/phy2.15869. https://pubmed.ncbi.nlm.nih.gov/38054572/
2. Zhao, Yu, Zhang, Qian, Yan, Yuzhu, Mei, Cheng, Zou, Tianyu. 2022. Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks. In Phytotherapy research : PTR, 37, 1850-1863. doi:10.1002/ptr.7702. https://pubmed.ncbi.nlm.nih.gov/36515407/
3. Ye, Xiaomin, Zhong, Peiqu, Chen, Qiongfang, Zhang, Jiayuan, Zhao, Lijian. 2025. PFOS-Induced Perturbations in Trophoblast Functions through the Oip5os1/miR-155/Rnd3 Axis in PE. In Chemical research in toxicology, 38, 236-251. doi:10.1021/acs.chemrestox.4c00184. https://pubmed.ncbi.nlm.nih.gov/39807729/
4. Wooten, Serena, Smith, Keriayn N. . Long non-coding RNA OIP5-AS1 (Cyrano): A context-specific regulator of normal and disease processes. In Clinical and translational medicine, 12, e706. doi:10.1002/ctm2.706. https://pubmed.ncbi.nlm.nih.gov/35040588/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen