C57BL/6NCya-Adisspem1flox/Cya
Common Name
Adissp-flox
Product ID
S-CKO-13629
Backgroud
C57BL/6NCya
Strain ID
CKOCMP-67326-Adissp-B6N-VA
When using this mouse strain in a publication, please cite “Adissp-flox Mouse (Catalog S-CKO-13629) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Adissp-flox
Strain ID
CKOCMP-67326-Adissp-B6N-VA
Gene Name
Product ID
S-CKO-13629
Gene Alias
1700037H04Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000103188
NCBI RefSeq
NM_026091
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Overview of Gene Research
Adissp, also known as UPF0687 protein or human C20orf27 homolog, is an adipokine. It is a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis. Its expression is adipose-specific and highly enriched in brown adipose tissue (BAT). Adissp secretion is stimulated by β3-adrenergic activation, and it is involved in pathways related to energy metabolism, which is of great biological importance in obesity and diabetes research [1,2].
Adipose-specific Adissp knockout mice show defects in WAT browning. These mice are more susceptible to high-fat diet-induced obesity and hyperglycemia. This indicates that Adissp plays a crucial role in the browning process of WAT, and its absence disrupts normal energy metabolism, leading to the development of obesity and related metabolic disorders [1].
In conclusion, Adissp is a major upstream signaling component in adipose thermogenesis. The study of Adissp knockout mouse models has revealed its essential function in maintaining normal WAT thermogenesis and glucose homeostasis, contributing to a better understanding of the mechanisms underlying obesity and diabetes, and offering potential treatment avenues for these diseases [1].
References：
1. Chen, Qingbo, Huang, Lei, Pan, Dongning, Guertin, David A, Wang, Yong-Xu. 2022. A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. In Nature communications, 13, 7633. doi:10.1038/s41467-022-35335-w. https://pubmed.ncbi.nlm.nih.gov/36496438/
2. Nie, Tao, Lu, Jinli, Zhang, Hua, Mao, Liufeng. 2023. Latest advances in the regulatory genes of adipocyte thermogenesis. In Frontiers in endocrinology, 14, 1250487. doi:10.3389/fendo.2023.1250487. https://pubmed.ncbi.nlm.nih.gov/37680891/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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