C57BL/6JCya-Isoc2bem1flox/Cya
Common Name:
Isoc2b-flox
Product ID:
S-CKO-13686
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Isoc2b-flox
Strain ID
CKOCMP-67441-Isoc2b-B6J-VA
Gene Name
Product ID
S-CKO-13686
Gene Alias
0610042E07Rik; Isoc2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Isoc2bem1flox/Cya mice (Catalog S-CKO-13686) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000064547
NCBI RefSeq
NM_026158
Target Region
Exon 2~5
Size of Effective Region
~3.6 kb
Detailed Document
Overview of Gene Research
Isoc2b is a gene whose hypomethylated loci were found to be clustered in relation to aging processes in a study. While specific functions, common aliases, and associated pathways aren't elaborated in the provided abstract, the findings suggest its potential involvement in energy production, an aspect related to biological processes [1].
The study compared age-and tissue-specific methylation differences in the brain and spleen of young and aged mice. It was discovered that among the differentially methylated cytosines between young and old samples, hypomethylated loci were clustered around Isoc2b, along with other genes like Mid1, and genome-wide loci with binding sites for Foxa2 and Esr1, which are known to be important in development and aging. This indicates that Isoc2b may be associated with age-related methylation changes and potentially with biological processes related to aging [1].
In conclusion, Isoc2b appears to be associated with age-related methylation changes and may play a role in energy production processes related to aging. Although no gene knockout or conditional knockout mouse model findings were presented in the given abstract, the discovery of its hypomethylated loci clustering in aged mice provides a starting point for further in vivo functional studies to understand its exact role in the context of aging-related biological processes and potentially associated diseases.
References:
1. Uli, Nishanth, Michelen-Gomez, Eduardo, Ramos, Enrique I, Druley, Todd E. 2018. Age-specific changes in genome-wide methylation enrich for Foxa2 and estrogen receptor alpha binding sites. In PloS one, 13, e0203147. doi:10.1371/journal.pone.0203147. https://pubmed.ncbi.nlm.nih.gov/30256791/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen