C57BL/6JCya-Loxl4em1flox/Cya
Common Name:
Loxl4-flox
Product ID:
S-CKO-13761
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Loxl4-flox
Strain ID
CKOCMP-67573-Loxl4-B6J-VA
Gene Name
Product ID
S-CKO-13761
Gene Alias
4833426I20Rik; Loxc
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Loxl4em1flox/Cya mice (Catalog S-CKO-13761) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000026190
NCBI RefSeq
NM_053083
Target Region
Exon 5~9
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
Loxl4, short for Lysyl oxidase-like 4, is a member of the lysyl oxidase family. It is a copper and lysine tyrosylquinone-dependent amine oxidase. Its main function is to catalyze the cross-linking of elastin and collagen in the extracellular matrix, playing a crucial role in extracellular matrix formation and repair [1,4].
Genetic ablation of Loxl4 in mice markedly disrupts pathological collagen cross-linking and fibrosis in the lung, indicating that Loxl4 is the main lysyl oxidase activity underlying pathological collagen cross-linking and lung fibrosis [2]. However, abrogation of Loxl4 in mice does not induce a more severe thoracic or abdominal aortic aneurysm compared with wild-type mice, suggesting that Loxl4 may not play a major role in the development of angiotensin II-induced aortic aneurysm [3].
In conclusion, Loxl4 is essential for extracellular matrix cross-linking. Mouse models with Loxl4 knockout have been valuable in revealing its role in lung fibrosis and aortic aneurysm development. These findings contribute to understanding the mechanisms of related diseases and may provide insights for potential therapeutic strategies.
References：
1. Wang, Jiaming, Chen, Chaojian, Huang, Jiayi, Li, Enmin, Zou, Haiying. 2023. The possibilities of LOXL4 as a prognostic marker for carcinomas. In Amino acids, 55, 1519-1529. doi:10.1007/s00726-023-03343-9. https://pubmed.ncbi.nlm.nih.gov/37814029/
2. Ma, Hsiao-Yen, Li, Qingling, Wong, Weng Ruh, Sandoval, Wendy, Ding, Ning. 2023. LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung. In Science advances, 9, eadf0133. doi:10.1126/sciadv.adf0133. https://pubmed.ncbi.nlm.nih.gov/37235663/
3. Li, Huimin, Guo, Jun, Jia, Yiting, Kong, Wei, Li, Wei. 2021. LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice. In Genes, 12, . doi:10.3390/genes12040513. https://pubmed.ncbi.nlm.nih.gov/33807332/
4. Liu, Ruai, Li, Bin, Zi, Jiaji, Pu, Yuanqian, Xiong, Wei. 2024. The dual role of LOXL4 in the pathogenesis and development of human malignant tumors: a narrative review. In Translational cancer research, 13, 2026-2042. doi:10.21037/tcr-23-2003. https://pubmed.ncbi.nlm.nih.gov/38737700/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen