C57BL/6JCya-Iqcf3em1flox/Cya
Common Name:
Iqcf3-flox
Product ID:
S-CKO-14121
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Iqcf3-flox
Strain ID
CKOCMP-68265-Iqcf3-B6J-VA
Gene Name
Product ID
S-CKO-14121
Gene Alias
1700012F17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Iqcf3em1flox/Cya mice (Catalog S-CKO-14121) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000062917
NCBI RefSeq
NM_026645
Target Region
Exon 4~6
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Check the content of the review
Iqcf3, specific aliases are not mentioned in the provided reference. Currently, its essential function, associated pathways, and overall biological importance remain to be comprehensively defined, but genetic models could potentially be valuable for further exploration.
A gene-based association analysis in a study of keratitis in the UK Biobank cohort with 337,199 European-ancestry subjects identified Iqcf3 (p = 2.0×10⁻⁶) as a significant gene associated with keratitis. The overlap of Iqcf3 in SNP-based and gene-based analyses led to the identification of 33 hub genes, suggesting its potential role in the genomic loci underlying keratitis [1].
In conclusion, Iqcf3 has been identified as a candidate gene associated with keratitis through gene-based association analysis. Its discovery in the context of keratitis research may provide insights into the genetic mechanisms underlying this complex condition, which is the second most common cause of legal blindness worldwide [1].
References：
1. Xu, Yue, Yang, Xiao-Lin, Yang, Xiao-Long, Zhang, Lei, Zhang, Xiao-Feng. 2020. Functional Annotations of Single-Nucleotide Polymorphism (SNP)-Based and Gene-Based Genome-Wide Association Studies Show Genes Affecting Keratitis Susceptibility. In Medical science monitor : international medical journal of experimental and clinical research, 26, e922710. doi:10.12659/MSM.922710. https://pubmed.ncbi.nlm.nih.gov/32450567/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen