C57BL/6JCya-Fam114a1em1flox/Cya
Common Name:
Fam114a1-flox
Product ID:
S-CKO-14139
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fam114a1-flox
Strain ID
CKOCMP-68303-Fam114a1-B6J-VA
Gene Name
Product ID
S-CKO-14139
Gene Alias
1190001N04Rik; 9130005N14Rik; Noxp20
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fam114a1em1flox/Cya mice (Catalog S-CKO-14139) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000031080
NCBI RefSeq
NM_026667
Target Region
Exon 3
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Fam114a1, Family with Sequence Similarity 114 Member A1, is a gene with diverse functions. It is involved in regulating angiotensin II signaling, which is related to cardiac pathological remodeling [1]. Additionally, it may play a role in the development of cells like melanocytes, nerve cells, and those originating from the neural crest of the embryonic ectoderm [2].
In mouse models, homozygous KO of Fam114a1 reduces cardiomyocyte hypertrophy, inflammation, and cardiac fibrosis, while restoring cardiac function in angiotensin II-induced and MI-induced heart failure mouse models [1]. In melanocytes, inhibition of Fam114a1 increases proliferation, migration, and melanin synthesis proteins, and decreases apoptosis [2]. In hepatocellular carcinoma cells, suppression of Fam114a1 reduces cell proliferation and migration, promotes apoptosis, arrests the cell cycle, and inhibits epithelial-mesenchymal transition by modulating AKT1 [3].
In conclusion, Fam114a1 is a key regulator in multiple biological processes. Its knockout in mouse models has provided insights into its role in cardiac pathological remodeling, melanocyte function, and hepatocellular carcinoma development. These findings suggest that Fam114a1 could be a potential therapeutic target for related diseases [1,2,3].
References:
1. Subbaiah, Kadiam C Venkata, Wu, Jiangbin, Tang, Wai Hong Wilson, Yao, Peng. 2022. FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling. In JCI insight, 7, . doi:10.1172/jci.insight.152783. https://pubmed.ncbi.nlm.nih.gov/35671117/
2. Zhou, Miaoni, Lin, Fuquan, Wu, Xingang, Jin, Rong, Xu, Aie. 2021. Inhibition of Fam114A1 protects melanocytes from apoptosis through higher RACK1 expression. In Aging, 13, 24740-24752. doi:10.18632/aging.203712. https://pubmed.ncbi.nlm.nih.gov/34837888/
3. Zhang, Haifeng, Zeng, Yu, Ye, Chihua, Cai, Jianwu, Hu, Xiao. . Inhibition of FAM114A1 Suppresses Hepatocellular Carcinoma by Targeting AKT1 Signaling. In Annals of clinical and laboratory science, 54, 378-387. doi:. https://pubmed.ncbi.nlm.nih.gov/39048162/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen