C57BL/6JCya-Zfp740em1flox/Cya
Common Name:
Zfp740-flox
Product ID:
S-CKO-14289
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Zfp740-flox
Strain ID
CKOCMP-68744-Zfp740-B6J-VA
Gene Name
Product ID
S-CKO-14289
Gene Alias
1110034O07Rik; Znf740
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
15
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp740em1flox/Cya mice (Catalog S-CKO-14289) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000119800
NCBI RefSeq
NM_001289695
Target Region
Exon 3~6
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
Zfp740 is a gene whose function is associated with the regulation of memory NK cell persistence. It is part of the Themis2-Zfp740 pathway in natural killer (NK) cells [1].
In a study, Zfp740-deficient NK cells expressing Ly49H showed an increase in the number of memory NK cells and enhanced effector function of these memory NK cells. This indicates that Zfp740 negatively regulates the differentiation and function of memory NK cells [1].
In conclusion, Zfp740 plays a crucial role in quantitatively and qualitatively regulating NK cell memory formation through its involvement in the Themis2-Zfp740 pathway. The use of Zfp740-deficient (KO) mouse models has revealed its importance in the context of NK cell-mediated immune responses, potentially providing insights into better understanding and modulating immune protection against certain infections [1].
References：
1. Nabekura, Tsukasa, Deborah, Elfira Amalia, Tahara, Saeko, Muratani, Masafumi, Shibuya, Akira. 2023. Themis2 regulates natural killer cell memory function and formation. In Nature communications, 14, 7200. doi:10.1038/s41467-023-42578-8. https://pubmed.ncbi.nlm.nih.gov/37938555/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen