C57BL/6JCya-Ddoem1flox/Cya
Common Name:
Ddo-flox
Product ID:
S-CKO-14844
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ddo-flox
Strain ID
CKOCMP-70503-Ddo-B6J-VA
Gene Name
Product ID
S-CKO-14844
Gene Alias
5330420D20Rik; 5730402C02Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ddoem1flox/Cya mice (Catalog S-CKO-14844) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019977
NCBI RefSeq
NM_027442
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Check the content of the review
Ddo, whose exact function and associated pathways are being explored, is related to the peroxisome-related pathways. Peroxisomes are involved in lipid metabolism and regulation of reactive oxygen species, indicating the potential importance of Ddo in these biological processes [1].
In a study on non-small cell lung cancer (NSCLC), genetic variants in Ddo were investigated. Single-nucleotide polymorphism (SNP) rs9384742 in Ddo was significantly associated with NSCLC overall survival. The minor allele of rs9384742 DDO was associated with decreased messenger RNA (mRNA) expression levels, and DDO expression was decreased in NSCLC tumor tissue. This suggests that Ddo genetic variants may influence gene regulation and could be potential predictors of NSCLC overall survival [1].
In conclusion, Ddo is associated with the peroxisome-related pathways and may play a role in gene regulation. The study of Ddo through genetic variants in NSCLC patients provides insights into its potential importance in this disease area, indicating that further research on Ddo could offer a better understanding of NSCLC development and progression [1].
References：
1. Chen, Allan S, Liu, Hongliang, Wu, Yufeng, Christiani, David C, Wei, Qingyi. 2022. Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival. In Molecular carcinogenesis, 61, 619-628. doi:10.1002/mc.23400. https://pubmed.ncbi.nlm.nih.gov/35502931/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen