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C57BL/6JCya-Ulk3em1flox/Cya
Common Name:
Ulk3-flox
Product ID:
S-CKO-15159
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ulk3-flox
Strain ID
CKOCMP-71742-Ulk3-B6J-VA
Gene Name
Ulk3
Product ID
S-CKO-15159
Gene Alias
1200015E14Rik
Background
C57BL/6JCya
NCBI ID
71742
Modification
Conditional knockout
Chromosome
9
Phenotype
MGI:1918992
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ulk3em1flox/Cya mice (Catalog S-CKO-15159) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000053230
NCBI RefSeq
NM_027895
Target Region
Exon 2~4
Size of Effective Region
~1.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ulk3, or unc-51 like kinase 3, is a serine/threonine protein kinase involved in multiple cellular processes. It plays crucial roles in autophagy, cell division, and regulation of the Sonic hedgehog pathway. It also has functions in the context of epigenetic regulation, being involved in histone arginine methylation, which is important for epidermal homeostasis and oncogenesis [1].

In keratinocytes and SCC-derived cells, gene silencing or deletion of Ulk3 reduces proliferation and clonogenicity, and affects transcription related to stem cell-related and metabolism programs [1]. In BIN1-deficient mouse hippocampal neurons, reducing Ulk3 activity mitigates dendritic regression, hippocampal volume loss, and spatial memory decline [2]. In breast cancer, Mendelian randomization analysis associated Ulk3 with the disease [3]. In epilepsy, a Mendelian randomization study found that increased Ulk3 levels were associated with a decreased risk of focal epilepsy [4].

In summary, Ulk3 is essential for multiple cellular processes such as autophagy and cell division. Model-based research, including gene-silencing experiments in cell lines and in vivo studies in mice, has revealed its roles in various disease conditions like cancer and neurological disorders. These findings contribute to understanding the underlying mechanisms of these diseases and may provide potential therapeutic targets.

References:
1. Goruppi, Sandro, Clocchiatti, Andrea, Bottoni, Giulia, Simon, Christian, Paolo Dotto, G. 2023. The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome. In Nature communications, 14, 887. doi:10.1038/s41467-023-36410-6. https://pubmed.ncbi.nlm.nih.gov/36797248/
2. Jin, Yuxi, Zhao, Lin, Zhang, Yanli, Xiao, Ming, Sheng, Chengyu. 2024. BIN1 deficiency enhances ULK3-dependent autophagic flux and reduces dendritic size in mouse hippocampal neurons. In Autophagy, 21, 223-242. doi:10.1080/15548627.2024.2393932. https://pubmed.ncbi.nlm.nih.gov/39171951/
3. Zhang, Naiqi, Li, Yanni, Sundquist, Jan, Sundquist, Kristina, Ji, Jianguang. 2023. Identifying actionable druggable targets for breast cancer: Mendelian randomization and population-based analyses. In EBioMedicine, 98, 104859. doi:10.1016/j.ebiom.2023.104859. https://pubmed.ncbi.nlm.nih.gov/38251461/
4. Liu, Baolai, Fan, Keyi, Zheng, Xinyi, Zhang, Heyi, Zhang, Shengxiao. 2024. Genetic associations between ULK3 and epilepsy: a two-sample Mendelian randomization study. In Frontiers in neurology, 15, 1376314. doi:10.3389/fneur.2024.1376314. https://pubmed.ncbi.nlm.nih.gov/39188705/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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