C57BL/6JCya-Lancl2em1flox/Cya
Common Name:
Lancl2-flox
Product ID:
S-CKO-15212
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Lancl2-flox
Strain ID
CKOCMP-71835-Lancl2-B6J-VA
Gene Name
Product ID
S-CKO-15212
Gene Alias
1700003F10Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lancl2em1flox/Cya mice (Catalog S-CKO-15212) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000050077
NCBI RefSeq
NM_133737
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
Lancl2, short for Lanthionine synthetase C-like 2, exhibits diverse functions. It is involved in multiple biological processes such as redox balance, immunoregulation, and cell proliferation. In redox regulation, it plays a role in testicular homeostasis [2]. Immunologically, it enhances regulatory CD4+ T cell responses, regulating mucosal immunity [1]. Lancl2 is also related to signaling pathways like the Akt and AMPK/PGC-1α/Sirt1 axes [3,4,5].
Genetic ablation of Lancl2 in mice reveals its significance. Inflammatory bowel disease (IBD) and lupus models show severe inflammatory phenotypes upon Lancl2 knockout, indicating its importance in immunoregulation [1]. In Lancl2 knockout mice, sperm parameters are damaged, with disrupted testicular redox homeostasis and acrosomal maturation defects, highlighting its role in testicular function [2]. In EGFR-mutant lung adenocarcinoma, Lancl2 knockdown reduces cell proliferation and enhances apoptosis in vitro and suppresses tumor growth in vivo, suggesting its role in promoting tumorigenesis [4].
In conclusion, Lancl2 is crucial for multiple biological functions including testicular redox balance and immunoregulation. Mouse knockout models have significantly contributed to understanding its role in diseases like IBD, lupus, and certain cancers, providing insights into potential therapeutic strategies targeting Lancl2 in these disease areas.
References:
1. Tubau-Juni, Nuria, Hontecillas, Raquel, Leber, Andrew J, Alva, Sameeksha S, Bassaganya-Riera, Josep. . Treating Autoimmune Diseases With LANCL2 Therapeutics: A Novel Immunoregulatory Mechanism for Patients With Ulcerative Colitis and Crohn's Disease. In Inflammatory bowel diseases, 30, 671-680. doi:10.1093/ibd/izad258. https://pubmed.ncbi.nlm.nih.gov/37934790/
2. Zhao, Yanling, Wang, Jichen, Shi, Shuai, Chen, Zhengli, Huang, Chao. 2024. LanCL2 Implicates in Testicular Redox Homeostasis and Acrosomal Maturation. In Antioxidants (Basel, Switzerland), 13, . doi:10.3390/antiox13050534. https://pubmed.ncbi.nlm.nih.gov/38790639/
3. Scarano, Naomi, Di Palma, Francesco, Origlia, Nicola, Cichero, Elena, Cavalli, Andrea. 2023. New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists. In Pharmaceutics, 15, . doi:10.3390/pharmaceutics15122754. https://pubmed.ncbi.nlm.nih.gov/38140095/
4. Lou, Yuqing, Xu, Jianlin, Zhang, Yanwei, Lu, Jun, Han, Baohui. 2021. Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis. In Cell death & disease, 12, 170. doi:10.1038/s41419-021-03439-8. https://pubmed.ncbi.nlm.nih.gov/33568630/
5. Zeng, Min, van der Donk, Wilfred A, Chen, Jie. 2014. Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt. In Molecular biology of the cell, 25, 3954-61. doi:10.1091/mbc.E14-01-0004. https://pubmed.ncbi.nlm.nih.gov/25273559/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen