C57BL/6JCya-Sting1em1flox/Cya
Common Name:
Sting1-flox
Product ID:
S-CKO-15494
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Sting1-flox
Strain ID
CKOCMP-72512-Sting1-B6J-VA
Gene Name
Product ID
S-CKO-15494
Gene Alias
2610307O08Rik; ERIS; MPYS; Mita; STING; STING-beta; Tmem173
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
18
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sting1em1flox/Cya mice (Catalog S-CKO-15494) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000115728
NCBI RefSeq
NM_028261
Target Region
Exon 6~8
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Sting1, also known as STING or TMEM173, is an endoplasmic reticulum protein. It plays a fundamental role in the production of type I interferons (IFNs) and pro-inflammatory cytokines in response to microbial or host-derived DNA by activating multiple transcription factors. It is a key component of the cGAS-STING pathway, which is crucial for innate immunity, and is implicated in various biological processes such as autophagy and different cell death modalities [1].
In a study on crescentic glomerulonephritis, Sting1-/-mice with nephrotoxic nephritis had lower kidney cytokine expression, milder kidney infiltration by immune cells, and decreased disease severity. Pharmacological STING1 inhibition mirrored these findings, indicating that STING1 activation is a pathological mechanism in this disease [2].
In conclusion, Sting1 is essential for the cGAS-STING pathway in innate immunity, regulating autophagy and cell death. The use of Sting1 knockout mouse models has revealed its role in immune-mediated diseases like crescentic glomerulonephritis, providing insights into potential therapeutic targets for such conditions.
References：
1. Zhang, Ruoxi, Kang, Rui, Tang, Daolin. 2021. The STING1 network regulates autophagy and cell death. In Signal transduction and targeted therapy, 6, 208. doi:10.1038/s41392-021-00613-4. https://pubmed.ncbi.nlm.nih.gov/34078874/
2. García-Giménez, Jorge, Córdoba-David, Gina, Rayego-Mateos, Sandra, Ortiz, Alberto, Ramos, Adrián M. 2023. STING1 deficiency ameliorates immune-mediated crescentic glomerulonephritis in mice. In The Journal of pathology, 261, 309-322. doi:10.1002/path.6177. https://pubmed.ncbi.nlm.nih.gov/37650295/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen