C57BL/6JCya-Asphd2em1flox/Cya
Common Name:
Asphd2-flox
Product ID:
S-CKO-15589
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Asphd2-flox
Strain ID
CKOCMP-72898-Asphd2-B6J-VA
Gene Name
Product ID
S-CKO-15589
Gene Alias
2900006N09Rik; 9230106G13Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Asphd2em1flox/Cya mice (Catalog S-CKO-15589) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000031291
NCBI RefSeq
NM_001357015
Target Region
Exon 1
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Asphd2, while no common aliases are given in the provided references, is a gene whose expression has been associated with certain biological pathways. Its exact function remains to be fully elucidated, but its regulation has been linked to metabolism-related pathways as well as viral replication cycles [1].
In a study on monkeypox virus (MPV) infection of HeLa cells, genes like Asphd2 were found to be regulated in the 2-hour infection group, indicating an association with clusters and pathways of metabolism and viral replication cycles [1]. In another study focused on septic melioidosis, a diagnostic 6-mRNA signature including Asphd2 was identified. This signature could distinguish sepsis caused by Burkholderia pseudomallei from that caused by other organisms, suggesting Asphd2's potential role in host-pathogen interaction [2].
In conclusion, Asphd2 appears to be involved in metabolism-related processes and viral replication cycles during MPV infection [1]. Additionally, it has potential as a biomarker in the diagnosis of septicaemic melioidosis, highlighting its importance in understanding host-pathogen interactions [2].
References：
1. Anuraga, Gangga, Lang, Jilu, Xuan, Do Thi Minh, Wang, Wei-Jan, Wang, Chih-Yang. 2023. Integrated bioinformatics approaches to investigate alterations in transcriptomic profiles of monkeypox infected human cell line model. In Journal of infection and public health, 17, 60-69. doi:10.1016/j.jiph.2023.10.035. https://pubmed.ncbi.nlm.nih.gov/37992435/
2. Yin, Li, Chen, Yuanyuan, Fu, Tingting, Liu, Lin, Xia, Qianfeng. . Identification of candidate blood biomarkers for the diagnosis of septicaemic melioidosis based on WGCNA. In Artificial cells, nanomedicine, and biotechnology, 50, 252-259. doi:10.1080/21691401.2022.2126490. https://pubmed.ncbi.nlm.nih.gov/36191125/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen