C57BL/6JCya-Prrc1em1flox/Cya
Common Name:
Prrc1-flox
Product ID:
S-CKO-15635
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Prrc1-flox
Strain ID
CKOCMP-73137-Prrc1-B6J-VA
Gene Name
Product ID
S-CKO-15635
Gene Alias
1190002C06Rik; 2310058D16Rik; 3110038B19Rik; 9430085A19Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
18
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Prrc1em1flox/Cya mice (Catalog S-CKO-15635) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025490
NCBI RefSeq
NM_028447
Target Region
Exon 5
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Prrc1, whose functions are still being explored, has been implicated in several biological processes. It contains a proline-rich domain and is involved in regulating anterograde trafficking. It is recruited to endoplasmic reticulum (ER) exit sites, interacts with the inner COPII coat, and influences the membrane association of COPII [2].
In secondary acute lymphoblastic leukemia (sALL), a fusion between 5'MLL and 3'PRRC1 was identified in a patient with sALL following chemotherapy for diffuse large B cell lymphoma [1]. In non-small cell lung cancer, PRRC1 was found to potentially play a role in MUC5AC glycosylation as it interacted and colocalized with MUC5AC in the Golgi [4]. In head and neck cancer, PRRC1 was identified as an independent prognostic factor through analysis of survival-associated alternative splicing events [5]. Also, in a study of children and adolescents, PRRC1 gene expression was negatively associated with deprivation [6]. In late adulthood, a region on chromosome 5 spanning the PRRC1 gene was significant at a genome-wide 10% empirical threshold in relation to fluid intelligence, and gene methylation analysis provided support for the association of PRRC1 and fluid intelligence [3].
In summary, Prrc1 appears to be involved in multiple biological processes and disease conditions. Its role in anterograde trafficking provides insights into cellular transport mechanisms. In diseases such as sALL, non-small cell lung cancer, head and neck cancer, and its association with deprivation and fluid intelligence, Prrc1 shows potential as a biomarker or therapeutic target. The findings from these studies contribute to understanding the complex functions of Prrc1 in normal biology and disease.
References:
1. Douet-Guilbert, Nathalie, Eveillard, Jean-Richard, Meyer, Claus, Marschalek, Rolf, De Braekeleer, Marc. 2014. MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature. In Leukemia research, 38, 1316-9. doi:10.1016/j.leukres.2014.08.011. https://pubmed.ncbi.nlm.nih.gov/25205603/
2. Huang, Yan, Yin, Haidi, Li, Baiying, Yao, Zhong-Ping, Guo, Yusong. . An in vitro vesicle formation assay reveals cargo clients and factors that mediate vesicular trafficking. In Proceedings of the National Academy of Sciences of the United States of America, 118, . doi:10.1073/pnas.2101287118. https://pubmed.ncbi.nlm.nih.gov/34433667/
3. Rowe, Suzanne J, Rowlatt, Amy, Davies, Gail, Deary, Ian J, Tenesa, Albert. 2013. Complex variation in measures of general intelligence and cognitive change. In PloS one, 8, e81189. doi:10.1371/journal.pone.0081189. https://pubmed.ncbi.nlm.nih.gov/24349040/
4. Appadurai, Muthamil Iniyan, Chaudhary, Sanjib, Shah, Ashu, Ganti, Apar Kishor, Lakshmanan, Imayavaramban. 2025. ST6GalNAc-I regulates tumor cell sialylation via NECTIN2/MUC5AC-mediated immunosuppression and angiogenesis in non-small cell lung cancer. In The Journal of clinical investigation, 135, . doi:10.1172/JCI186863. https://pubmed.ncbi.nlm.nih.gov/40371640/
5. Liang, Ying, Song, Jukun, He, Dengqi, Yin, Xinhai, Liu, Jianguo. 2019. Systematic analysis of survival-associated alternative splicing signatures uncovers prognostic predictors for head and neck cancer. In Journal of cellular physiology, 234, 15836-15846. doi:10.1002/jcp.28241. https://pubmed.ncbi.nlm.nih.gov/30740675/
6. Ota, Vanessa Kiyomi, Oliveira, Adrielle Martins, Bugiga, Amanda Victória Gomes, Carvalho, Carolina Muniz, Belangero, Sintia Iole. 2025. Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study. In Frontiers in psychiatry, 16, 1505421. doi:10.3389/fpsyt.2025.1505421. https://pubmed.ncbi.nlm.nih.gov/40018685/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen