C57BL/6JCya-Sgpp1em1flox/Cya
Common Name:
Sgpp1-flox
Product ID:
S-CKO-17013
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Sgpp1-flox
Strain ID
CKOCMP-81535-Sgpp1-B6J-VA
Gene Name
Product ID
S-CKO-17013
Gene Alias
SPP; SPP1; Spph1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Sgpp1em1flox/Cya mice (Catalog S-CKO-17013) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021450
NCBI RefSeq
NM_030750
Target Region
Exon 1
Size of Effective Region
~4.5 kb
Detailed Document
Overview of Gene Research
Sgpp1, sphingosine-1-phosphate phosphatase 1, is an enzyme that dephosphorylates sphingosine-1-phosphate (S1P) into sphingosine, thus influencing the sphingosine-S1P balance. It is involved in multiple biological processes such as lipid metabolism, and is associated with pathways like mTORC1 signaling and fatty acid metabolism [1].
In multiple myeloma, GFI1-dependent repression of SGPP1 increases cell survival by modulating sphingolipid metabolism to raise S1P levels, protecting c-Myc protein stability [2]. In colorectal cancer, sevoflurane inhibits cell proliferation, migration and invasion through regulating the circ_0000423/miR-525-5p/SGPP1 network [3]. In gastric cancer, down-regulation of SGPP1 is associated with lymph node and distant metastasis, and its knockdown promotes cell invasion and migration [4].
In conclusion, Sgpp1 plays a crucial role in lipid metabolism-related biological processes. Studies on Sgpp1 using loss-of-function models in diseases like multiple myeloma, colorectal cancer, and gastric cancer have revealed its significance in cancer cell survival, proliferation, migration, and metastasis, providing potential therapeutic targets for these diseases.
References:
1. Jia, Yuanmin, Wang, Haixia, Ma, Bin, Wang, Jin, Chen, Ou. 2024. Lipid metabolism-related genes are involved in the occurrence of asthma and regulate the immune microenvironment. In BMC genomics, 25, 129. doi:10.1186/s12864-023-09795-3. https://pubmed.ncbi.nlm.nih.gov/38297226/
2. Petrusca, Daniela N, Mulcrone, Patrick L, Macar, David A, Galson, Deborah L, Roodman, G David. 2022. GFI1-Dependent Repression of SGPP1 Increases Multiple Myeloma Cell Survival. In Cancers, 14, . doi:10.3390/cancers14030772. https://pubmed.ncbi.nlm.nih.gov/35159039/
3. Kang, Xiaofang, Li, Xiaocong, Li, Yanli. 2022. Sevoflurane Suppresses the Proliferation, Migration and Invasion of Colorectal Cancer Through Regulating Circ_0000423/miR-525-5p/SGPP1 Network. In Cellular and molecular bioengineering, 15, 219-230. doi:10.1007/s12195-021-00717-5. https://pubmed.ncbi.nlm.nih.gov/35401845/
4. Gao, Xiang Y, Li, Lin, Wang, Xiao H, Jiang, Wen G, Ji, Jia F. 2015. Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: Clinical implications. In Oncology reports, 34, 1977-87. doi:10.3892/or.2015.4162. https://pubmed.ncbi.nlm.nih.gov/26239167/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen