C57BL/6JCya-Ifi44em1flox/Cya
Common Name
Ifi44-flox
Product ID
S-CKO-17389
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-99899-Ifi44-B6J-VA
Status
When using this mouse strain in a publication, please cite “Ifi44-flox Mouse (Catalog S-CKO-17389) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ifi44-flox
Strain ID
CKOCMP-99899-Ifi44-B6J-VA
Gene Name
Product ID
S-CKO-17389
Gene Alias
p44, MTAP44, A430056A10Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000029671
NCBI RefSeq
NM_133871
Target Region
Exon 4~5
Size of Effective Region
~1.6 kb
Overview of Gene Research
Ifi44, an interferon-alfa inducible protein, is associated with the immune response, especially in relation to viral and bacterial infections. It is involved in interferon-related pathways and has been linked to various biological processes, potentially playing a role in disease development and immune regulation [1,2].
In vitro studies have shown that Ifi44 inhibits HIV-1 replication by suppressing HIV-1 LTR promoter activity, affecting viral transcription [1]. In RA patients, it was identified as a hub gene and an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infections, negatively regulating the IFN signaling pathway to promote viral and bacterial proliferation [2]. In head and neck squamous cell carcinoma, ACSL4 upregulates Ifi44 expression, promoting cell proliferation and invasiveness [3].
In conclusion, Ifi44 is an interferon-inducible protein with a role in the immune response to infections and in certain disease conditions. Studies have shown its significance in HIV-1 latency, immune evasion in RA, and cancer cell behavior, highlighting its potential as a biomarker and therapeutic target in these disease areas.
References：
1. Power, Derek, Santoso, Netty, Dieringer, Michael, Miao, Hongyu, Zhu, Jian. 2015. IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. In Virology, 481, 142-50. doi:10.1016/j.virol.2015.02.046. https://pubmed.ncbi.nlm.nih.gov/25776761/
2. Zheng, Qingcong, Wang, Du, Lin, Rongjie, Lv, Qi, Wang, Wanming. 2022. IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA. In Frontiers in immunology, 13, 1013322. doi:10.3389/fimmu.2022.1013322. https://pubmed.ncbi.nlm.nih.gov/36189314/
3. Rupa, Darius, Chuang, Hao-Wen, Hu, Chung-En, Lee, Herng-Sheng, Yuan, Ta-Chun. 2024. ACSL4 upregulates IFI44 and IFI44L expression and promotes the proliferation and invasiveness of head and neck squamous cell carcinoma cells. In Cancer science, 115, 3026-3040. doi:10.1111/cas.16236. https://pubmed.ncbi.nlm.nih.gov/38989827/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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