C57BL/6JCya-Fetubem1flox/Cya
Common Name:
Fetub-flox
Product ID:
S-CKO-17568
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Fetub-flox
Strain ID
CKOCMP-59083-Fetub-B6J-VC
Gene Name
Product ID
S-CKO-17568
Gene Alias
2310011O17Rik; D17980; Gugu
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
16
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fetubem1flox/Cya mice (Catalog S-CKO-17568) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023587
NCBI RefSeq
NM_021564
Target Region
Exon 4
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Fetub, also known as fetuin B, is a glycoprotein mainly synthesized and secreted by the liver. It is involved in multiple physiological and pathological processes. FETUB can act as an inhibitor of neprilysin (NEP), and is associated with pathways related to glucose metabolism, inflammatory response, and may play roles in cell-cell interactions. It has been implicated in various diseases, highlighting its biological importance [1,2,3].
In asthma, a lung-specific FETUB knockdown mouse model was used. The results showed that knockdown of FETUB restored NEP activity, reduced neuropeptides CGRP and SP, and improved airway inflammation and hyperresponsiveness. This indicates that epithelial-derived FETUB exacerbates asthma through the inhibition of NEP activity and the resultant accumulation of CGRP and SP [1].
In conclusion, FETUB has diverse functions in different biological processes. The use of gene-knockout (KO) mouse models, like the lung-specific FETUB knockdown model in asthma research, has been crucial in revealing its role in disease conditions. These studies help in understanding the mechanisms underlying diseases such as asthma, providing potential targets for treatment.
References：
1. Sun, Peng, Hua, Qi, Fu, Heng, Xia, Rong, Yao, Xin. 2025. Epithelial FETUB-mediated the inhibition of NEP activity aggravates asthma. In International immunopharmacology, 152, 114397. doi:10.1016/j.intimp.2025.114397. https://pubmed.ncbi.nlm.nih.gov/40064057/
2. Zhang, Wenyi, Wang, Xin, Tian, Shuwei, Wang, Jianming, Zhou, Aiyi. . Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells. In Investigative ophthalmology & visual science, 65, 16. doi:10.1167/iovs.65.12.16. https://pubmed.ncbi.nlm.nih.gov/39382879/
3. Wang, Xiao, Lyu, Hong-Yan, Chen, De-Quan, Chang, Bo, Yao, Ting-Ting. . [Research progress of fetuin-B in the female reproductive system]. In Sheng li xue bao : [Acta physiologica Sinica], 76, 1019-1031. doi:. https://pubmed.ncbi.nlm.nih.gov/39780577/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen