C57BL/6NCya-Fam167bem1flox/Cya
Common Name:
Fam167b-flox
Product ID:
S-CKO-17940
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fam167b-flox
Strain ID
CKOCMP-230766-Fam167b-B6N-VA
Gene Name
Product ID
S-CKO-17940
Gene Alias
SEC
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Fam167bem1flox/Cya mice (Catalog S-CKO-17940) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000052835
NCBI RefSeq
NM_182783
Target Region
Exon 1~2
Size of Effective Region
~2.1 kb
Detailed Document
Overview of Gene Research
Fam167b, a member of the FAM167 gene family, along with FAM167A, is evolutionarily conserved and not homologous to other annotated genes. The encoded protein, denoted as DIORA-2, is characterized by a high content of intrinsic disorder. However, its exact function, associated pathways, and overall biological importance are yet to be fully elucidated. Genetic models could potentially be valuable in further exploring its role [1].
The FAM167 gene family was investigated in the context of rheumatic diseases. Autoimmune risk genotypes within the FAM167A-BLK locus lead to increased expression of FAM167A. FAM167B, while not the primary focus, was cloned from human peripheral blood mononuclear cells along with FAM167A. Gene conservation and protein properties of the family were analyzed. Although no specific KO/CKO mouse model data for Fam167b was presented, the overall study of the gene family provides a foundation for understanding Fam167b's potential role in disease pathogenesis [1].
In conclusion, while the full-fledged biological functions of Fam167b remain unclear, research on the FAM167 gene family indicates its potential importance in rheumatic disease pathogenesis. Future in-vivo studies, such as gene knockout or conditional knockout mouse models of Fam167b, could shed more light on its specific functions and contributions to disease areas, helping to further understand the underlying mechanisms of rheumatic diseases.
References：
1. Mentlein, L, Thorlacius, G E, Meneghel, L, Espinosa, A, Wahren-Herlenius, M. 2018. The rheumatic disease-associated FAM167A-BLK locus encodes DIORA-1, a novel disordered protein expressed highly in bronchial epithelium and alveolar macrophages. In Clinical and experimental immunology, 193, 167-177. doi:10.1111/cei.13138. https://pubmed.ncbi.nlm.nih.gov/29663334/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen