Rgs7bp, also known as R7bp, is a palmitoylated membrane-anchoring protein. It facilitates Gαi/o-directed GTPase activating protein activity mediated by the Gβ5/R7-RGS complex, playing a role in G-protein-coupled receptor (GPCR) signaling, which is involved in many physiological functions [1].

In a knockout mouse model of R7bp (Rgs7bp), scratching responses to multiple pruritogens were diminished, indicating its key role in itch sensation [1]. In orofacial inflammation mouse models, differential gene expression analysis in trigeminal ganglion neurons identified Rgs7bp as potentially associated with pain modulation [2].

In conclusion, Rgs7bp is crucial for regulating itch sensation and may be involved in pain modulation. The gene knockout mouse models have been instrumental in revealing these functions, providing potential therapeutic targets for pathological itch and orofacial inflammatory pain.