C57BL/6JCya-Arl13aem1flox/Cya
Common Name
Arl13a-flox
Product ID
S-CKO-18288
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-74448-Arl13a-B6J-VB
When using this mouse strain in a publication, please cite “Arl13a-flox Mouse (Catalog S-CKO-18288) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Arl13a-flox
Strain ID
CKOCMP-74448-Arl13a-B6J-VB
Gene Name
Product ID
S-CKO-18288
Gene Alias
4933422M21Rik, Arl13
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000064476
NCBI RefSeq
NM_028947
Target Region
Exon 4
Size of Effective Region
~1.1 kb
Overview of Gene Research
Arl13a, a member of the Arf-like (Arl) family of small GTP-binding proteins, is a close paralog to Arl13b. The Arl family proteins regulate numerous cellular functions and are crucial for cilia structure and signaling [1].
In zebrafish, during early cell division and gastrulation, arl13a is widely expressed, and its encoded protein localizes to microtubules in ciliated and dividing cells. However, by 2 days post-fertilization (dpf), its expression is downregulated and restricted to craniofacial structures, indicating it may not function in the zebrafish retina as arl13b does [1]. In cheetahs, mutations in ARL13A, along with three other genes (DEFB116, CFAP119, and NT5DC4), have been linked to male fertility and immune deficiencies, suggesting pseudogenization of ARL13A may contribute to reproductive and health challenges in this species [2,3].
In summary, Arl13a is involved in early zebrafish development and may have a role in craniofacial development. In cheetahs, its mutation seems to be associated with male fertility and immune-related issues. Research on Arl13a in these genetic models helps to understand its diverse biological functions and its implications in specific species-related health problems.
References：
1. Song, Ping, Perkins, Brian D. 2018. Developmental expression of the zebrafish Arf-like small GTPase paralogs arl13a and arl13b. In Gene expression patterns : GEP, 29, 82-87. doi:10.1016/j.gep.2018.07.002. https://pubmed.ncbi.nlm.nih.gov/30009987/
2. Ghader, Aryan. . Digest: Do weakly deleterious mutations exacerbate reproductive and health challenges in species with prolonged bottlenecks? In Evolution; international journal of organic evolution, 79, 885-886. doi:10.1093/evolut/qpaf046. https://pubmed.ncbi.nlm.nih.gov/40089805/
3. Peers, Jessica A, Nash, Will J, Haerty, Wilfried. . Gene pseudogenization in fertility-associated genes in cheetah (Acinonyx jubatus), a species with long-term low effective population size. In Evolution; international journal of organic evolution, 79, 574-585. doi:10.1093/evolut/qpaf005. https://pubmed.ncbi.nlm.nih.gov/39821281/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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