C57BL/6JCya-Ttc39aos1em1flox/Cya
Common Name:
Ttc39aos1-flox
Product ID:
S-CKO-18467
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ttc39aos1-flox
Strain ID
CKOCMP-102635290-Ttc39aos1-B6J-VA
Gene Name
Product ID
S-CKO-18467
Gene Alias
Gm12750; lincRNA-EPS
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ttc39aos1em1flox/Cya mice (Catalog S-CKO-18467) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000247239
NCBI RefSeq
NR_131195
Target Region
Exon 2~4
Size of Effective Region
~3.4 kb
Detailed Document
Overview of Gene Research
Ttc39aos1 is a lncRNA. LncRNAs are involved in various biological processes by regulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. While the exact function, associated pathways, and overall biological importance of Ttc39aos1 are not elaborated in the given reference, genetic models could potentially be useful in further elucidating these aspects.
In a study on non-alcoholic fatty liver disease (NAFLD), microarray data from mouse models (GSE24031 with 4 control and 4 model mice, GSE57425 with 3 control and 3 model mice) were analyzed. A set of lncRNAs and mRNAs were found to be differentially expressed in the development of NAFLD. Ttc39aos1 was identified as a potentially crucial biomarker for NAFLD [1].
In conclusion, Ttc39aos1 shows potential as a biomarker for NAFLD. The use of mouse models in this research helped identify its possible significance in the context of this liver disease, which may further contribute to understanding the molecular mechanisms of NAFLD and potentially lead to new diagnostic or therapeutic strategies.
References：
1. Ma, Tao-Tao, Huang, Cheng, Ni, Ying, Yang, You, Li, Jun. 2018. ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data. In Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 51, 871-885. doi:10.1159/000495384. https://pubmed.ncbi.nlm.nih.gov/30466110/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen