C57BL/6JCya-Garin5aem1flox/Cya
Common Name:
Garin5a-flox
Product ID:
S-CKO-18503
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Garin5a-flox
Strain ID
CKOCMP-75538-Garin5a-B6J-VA
Gene Name
Product ID
S-CKO-18503
Gene Alias
0610007G24Rik; 1700021N13Rik; 1700021P22Rik; Fam71e1; GARI-L5; GARIL5
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Garin5aem1flox/Cya mice (Catalog S-CKO-18503) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000107927
NCBI RefSeq
NM_028169
Target Region
Exon 4
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Garin5a, a member of the Golgi Associated RAB2 Interactors (GARINs; also known as FAM71) protein family, shows predominant expression in the testis and has a RAB2-binding domain. The GARINs are involved in processes related to sperm head morphogenesis, with RAB2 being responsible for membrane transport and vesicle trafficking [1].
In gene knockout (KO) mouse models, Garin5a-/-males were found to be subfertile. This indicates that Garin5a plays a role in male fertility, likely through its contribution to the correct morphogenesis of sperm heads [1].
In conclusion, Garin5a is essential for murine male fertility as demonstrated by the subfertility of Garin5a KO male mice. Its function in sperm head morphogenesis highlights the importance of this gene in reproductive biology, and further study of Garin5a using KO mouse models may provide more insights into male infertility mechanisms [1].
References：
1. Wang, Haoting, Iida-Norita, Rie, Mashiko, Daisuke, Miyata, Haruhiko, Ikawa, Masahito. 2024. Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. In PLoS genetics, 20, e1011337. doi:10.1371/journal.pgen.1011337. https://pubmed.ncbi.nlm.nih.gov/38935810/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen