C57BL/6JCya-Pbx3em1flox/Cya
Common Name:
Pbx3-flox
Product ID:
S-CKO-18769
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Pbx3-flox
Strain ID
CKOCMP-18516-Pbx3-B6J-VB
Gene Name
Product ID
S-CKO-18769
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pbx3em1flox/Cya mice (Catalog S-CKO-18769) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000040638
NCBI RefSeq
NM_016768
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Pbx3, a homeodomain-containing transcription factor of the pre-B cell leukemia (PBX) family, has extensive roles in early development and some adult processes. It can form specific and stable DNA interactions without co-factors. PBX3 is involved in multiple signaling pathways, such as the P2X1-PBX3-BCAT1 pathway in leukemogenesis [1], and is related to metabolic reprogramming like promoting the pentose phosphate pathway through enhancing G6PD expression in colorectal cancer [2].
In a murine acute myeloid leukemia (AML) model, P2X1 deletion, which affects the P2X1-PBX3-BCAT1 pathway, impaired leukemia-initiating cell (LIC) self-renewal capacities and decreased functional LIC numbers without affecting normal hematopoiesis, revealing the role of PBX3 in leukemogenesis [1]. In colorectal cancer, PBX3 promotes cancer progression by enhancing G6PD expression, indicating its role in metabolic-based tumor development [2].
In conclusion, PBX3 is crucial in processes like leukemogenesis and colorectal cancer progression. The study of PBX3 in relevant KO or disease-based models helps to understand its role in these diseases, providing potential targets for therapeutic strategies.
References:
1. He, Xiaoxiao, Xu, Yilu, Huang, Dan, Zhang, Yaping, Zheng, Junke. 2022. P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways. In Leukemia, 37, 265-275. doi:10.1038/s41375-022-01759-y. https://pubmed.ncbi.nlm.nih.gov/36418376/
2. Luo, Xinxin, Wei, Mankun, Li, Wenfang, Kasim, Vivi, Wu, Shourong. 2023. PBX3 promotes pentose phosphate pathway and colorectal cancer progression by enhancing G6PD expression. In International journal of biological sciences, 19, 4525-4538. doi:10.7150/ijbs.86279. https://pubmed.ncbi.nlm.nih.gov/37781025/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen