C57BL/6JCya-Pbx3em1flox/Cya
Common Name
Pbx3-flox
Product ID
S-CKO-18769
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-18516-Pbx3-B6J-VB
Status
When using this mouse strain in a publication, please cite “Pbx3-flox Mouse (Catalog S-CKO-18769) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pbx3-flox
Strain ID
CKOCMP-18516-Pbx3-B6J-VB
Gene Name
Product ID
S-CKO-18769
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000040638
NCBI RefSeq
NM_016768
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Overview of Gene Research
Pbx3, a homeodomain-containing transcription factor of the pre-B cell leukemia (PBX) family, has extensive roles in early development and some adult processes. It can form specific and stable DNA interactions without co-factors. PBX3 is involved in multiple signaling pathways, such as the P2X1-PBX3-BCAT1 pathway in leukemogenesis [1], and is related to metabolic reprogramming like promoting the pentose phosphate pathway through enhancing G6PD expression in colorectal cancer [2].
In a murine acute myeloid leukemia (AML) model, P2X1 deletion, which affects the P2X1-PBX3-BCAT1 pathway, impaired leukemia-initiating cell (LIC) self-renewal capacities and decreased functional LIC numbers without affecting normal hematopoiesis, revealing the role of PBX3 in leukemogenesis [1]. In colorectal cancer, PBX3 promotes cancer progression by enhancing G6PD expression, indicating its role in metabolic-based tumor development [2].
In conclusion, PBX3 is crucial in processes like leukemogenesis and colorectal cancer progression. The study of PBX3 in relevant KO or disease-based models helps to understand its role in these diseases, providing potential targets for therapeutic strategies.
References：
1. He, Xiaoxiao, Xu, Yilu, Huang, Dan, Zhang, Yaping, Zheng, Junke. 2022. P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways. In Leukemia, 37, 265-275. doi:10.1038/s41375-022-01759-y. https://pubmed.ncbi.nlm.nih.gov/36418376/
2. Luo, Xinxin, Wei, Mankun, Li, Wenfang, Kasim, Vivi, Wu, Shourong. 2023. PBX3 promotes pentose phosphate pathway and colorectal cancer progression by enhancing G6PD expression. In International journal of biological sciences, 19, 4525-4538. doi:10.7150/ijbs.86279. https://pubmed.ncbi.nlm.nih.gov/37781025/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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