C57BL/6JCya-Snord59aem1flox/Cya
Common Name
Snord59a-flox
Product ID
S-CKO-18771
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-115487514-Snord59a-B6J-VA
When using this mouse strain in a publication, please cite “Snord59a-flox Mouse (Catalog S-CKO-18771) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Snord59a-flox
Strain ID
CKOCMP-115487514-Snord59a-B6J-VA
Gene Name
Product ID
S-CKO-18771
Gene Alias
Gm25206
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000082844
NCBI RefSeq
XR_004936572
Target Region
Exon 1
Size of Effective Region
~140 bp
Overview of Gene Research
Snord59a is a small nucleolar RNA with a C/D motif, belonging to the SNORD family. These noncoding RNAs are known to regulate ribosomal RNA assembly and function [2].
In human anaphylaxis, Snord59a was found to be significantly up-regulated in severe anaphylaxis compared to healthy controls, suggesting its potential involvement in the pathogenesis of anaphylaxis [1].
In the context of bisphenol A (BPA) exposure in human prostaspheres, Snord59a expression was reduced. BPA-induced gene silencing of Snord59a was associated with altered recruitments of histone marks (H3K9me3, H3K4me3, and H3K27me3) to its 5'-regulatory/exonic sequences, and its expression was also shown to be reduced in prostate cancer compared with adjacent normal tissue [2].
In summary, Snord59a is involved in ribosomal RNA-related functions. Its dysregulation in anaphylaxis and prostate cancer, as demonstrated through these studies, highlights its importance in understanding the pathogenesis of these conditions. The findings from these studies on Snord59a contribute to a better understanding of the molecular mechanisms underlying anaphylaxis and prostate cancer development [1,2].
References：
1. McGrath, Francesca Marina, Francis, Abbie, Fatovich, Daniel M, Woo, Andrew, Bosio, Erika. 2021. Small nucleolar RNA networks are up-regulated during human anaphylaxis. In Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 51, 1310-1321. doi:10.1111/cea.13982. https://pubmed.ncbi.nlm.nih.gov/34228845/
2. Ho, Shuk-Mei, Cheong, Ana, Lam, Hung-Ming, Leung, Yuet-Kin, Prins, Gail S. 2015. Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. In Endocrinology, 156, 3984-95. doi:10.1210/en.2015-1067. https://pubmed.ncbi.nlm.nih.gov/26248216/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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