C57BL/6JCya-Timm17bem1flox/Cya
Common Name:
Timm17b-flox
Product ID:
S-CKO-18798
Background:
C57BL/6JCya
Product Type
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Genotype
Sex
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Basic Information
Strain Name
Timm17b-flox
Strain ID
CKOCMP-21855-Timm17b-B6J-VB
Gene Name
Product ID
S-CKO-18798
Gene Alias
17kDa; Sfc3; mTim17b
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
X
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Timm17bem1flox/Cya mice (Catalog S-CKO-18798) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000033498
NCBI RefSeq
NM_011591
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
TIMM17B, also known as translocase of inner mitochondrial membrane 17b, is a gene related to the mitochondrial protein translocation pathway. The human TIM23 complex, which is crucial for transporting mitochondrial precursor proteins to the matrix and inner membrane, has two orthologs of yeast Tim17, including TIMM17B. This indicates its importance in mitochondrial protein import machinery, an essential process for mitochondrial function and overall cell viability [4,6].
In breast cancer, TIMM17B shows significantly higher expression compared to paracancer tissues, and it is associated with immune infiltration, drug resistance, and ferroptosis. High expression of TIMM17B in basal breast cancer is related to a better prognosis. In heart failure patients with ischemic and dilated cardiomyopathy, TIMM17B is downregulated, suggesting its role in mitochondrial quality control, which is disrupted in heart failure. In primary biliary cholangitis, a region including TIMM17B shows a genome-wide significant locus. In degenerative ascending aortic aneurysm, TIMM17B is downregulated, and proteins related to mitochondrial dysfunction like it might be therapeutic targets [1,2,3,5].
In summary, TIMM17B is essential for mitochondrial protein translocation. Studies on it, including in disease models like breast cancer, heart failure, primary biliary cholangitis, and degenerative ascending aortic aneurysm, have revealed its diverse roles in disease-related biological processes. These findings contribute to understanding disease mechanisms and may offer potential diagnostic or therapeutic targets.
References:
1. . 2023. High Expression of TIMM17B Is a Potential Diagnostic and Prognostic Marker of Breast Cancer. In Cellular and molecular biology (Noisy-le-Grand, France), 69, 169-176. doi:10.14715/cmb/2023.69.3.25. https://pubmed.ncbi.nlm.nih.gov/37300670/
2. Svagusa, T, Sikiric, S, Milavic, M, Bakovic, P, Sedlic, F. 2023. Heart failure in patients is associated with downregulation of mitochondrial quality control genes. In European journal of clinical investigation, 53, e14054. doi:10.1111/eci.14054. https://pubmed.ncbi.nlm.nih.gov/37403271/
3. Asselta, Rosanna, Paraboschi, Elvezia M, Gerussi, Alessio, Seldin, Michael F, Invernizzi, Pietro. 2021. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis. In Gastroenterology, 160, 2483-2495.e26. doi:10.1053/j.gastro.2021.02.061. https://pubmed.ncbi.nlm.nih.gov/33675743/
4. Elancheliyan, Praveenraj, Maruszczak, Klaudia K, Serwa, Remigiusz Adam, Wasilewski, Michal, Chacinska, Agnieszka. 2024. OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase. In Cell reports, 43, 115038. doi:10.1016/j.celrep.2024.115038. https://pubmed.ncbi.nlm.nih.gov/39630581/
5. Almendra-Pegueros, Rafael, Barros-Membrilla, Antonio J, Pérez-Marlasca, Elvira, Rodriguez, Cristina, Galán, María. 2024. Identification of new therapeutic targets related to endoplasmic reticulum stress and mitochondrial dysfunction to reduce the risk of rupture in degenerative ascending aortic aneurysm. In Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis, , . doi:10.1016/j.arteri.2024.09.002. https://pubmed.ncbi.nlm.nih.gov/39424523/
6. Maruszczak, Klaudia K, Draczkowski, Piotr, Wnorowski, Artur, Chacinska, Agnieszka. 2024. Structure prediction analysis of human core TIM23 complex reveals conservation of the protein translocation mechanism. In FEBS open bio, 14, 1656-1667. doi:10.1002/2211-5463.13840. https://pubmed.ncbi.nlm.nih.gov/38837610/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen