Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Timm17bem1flox/Cya
Common Name:
Timm17b-flox
Product ID:
S-CKO-18798
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Timm17b-flox
Strain ID
CKOCMP-21855-Timm17b-B6J-VB
Gene Name
Timm17b
Product ID
S-CKO-18798
Gene Alias
17kDa; Sfc3; mTim17b
Background
C57BL/6JCya
NCBI ID
21855
Modification
Conditional knockout
Chromosome
X
Phenotype
MGI:1343176
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Timm17bem1flox/Cya mice (Catalog S-CKO-18798) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000033498
NCBI RefSeq
NM_011591
Target Region
Exon 3
Size of Effective Region
~0.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
TIMM17B, also known as translocase of inner mitochondrial membrane 17b, is a gene related to the mitochondrial protein translocation pathway. The human TIM23 complex, which is crucial for transporting mitochondrial precursor proteins to the matrix and inner membrane, has two orthologs of yeast Tim17, including TIMM17B. This indicates its importance in mitochondrial protein import machinery, an essential process for mitochondrial function and overall cell viability [4,6].

In breast cancer, TIMM17B shows significantly higher expression compared to paracancer tissues, and it is associated with immune infiltration, drug resistance, and ferroptosis. High expression of TIMM17B in basal breast cancer is related to a better prognosis. In heart failure patients with ischemic and dilated cardiomyopathy, TIMM17B is downregulated, suggesting its role in mitochondrial quality control, which is disrupted in heart failure. In primary biliary cholangitis, a region including TIMM17B shows a genome-wide significant locus. In degenerative ascending aortic aneurysm, TIMM17B is downregulated, and proteins related to mitochondrial dysfunction like it might be therapeutic targets [1,2,3,5].

In summary, TIMM17B is essential for mitochondrial protein translocation. Studies on it, including in disease models like breast cancer, heart failure, primary biliary cholangitis, and degenerative ascending aortic aneurysm, have revealed its diverse roles in disease-related biological processes. These findings contribute to understanding disease mechanisms and may offer potential diagnostic or therapeutic targets.

References:
1. . 2023. High Expression of TIMM17B Is a Potential Diagnostic and Prognostic Marker of Breast Cancer. In Cellular and molecular biology (Noisy-le-Grand, France), 69, 169-176. doi:10.14715/cmb/2023.69.3.25. https://pubmed.ncbi.nlm.nih.gov/37300670/
2. Svagusa, T, Sikiric, S, Milavic, M, Bakovic, P, Sedlic, F. 2023. Heart failure in patients is associated with downregulation of mitochondrial quality control genes. In European journal of clinical investigation, 53, e14054. doi:10.1111/eci.14054. https://pubmed.ncbi.nlm.nih.gov/37403271/
3. Asselta, Rosanna, Paraboschi, Elvezia M, Gerussi, Alessio, Seldin, Michael F, Invernizzi, Pietro. 2021. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis. In Gastroenterology, 160, 2483-2495.e26. doi:10.1053/j.gastro.2021.02.061. https://pubmed.ncbi.nlm.nih.gov/33675743/
4. Elancheliyan, Praveenraj, Maruszczak, Klaudia K, Serwa, Remigiusz Adam, Wasilewski, Michal, Chacinska, Agnieszka. 2024. OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase. In Cell reports, 43, 115038. doi:10.1016/j.celrep.2024.115038. https://pubmed.ncbi.nlm.nih.gov/39630581/
5. Almendra-Pegueros, Rafael, Barros-Membrilla, Antonio J, Pérez-Marlasca, Elvira, Rodriguez, Cristina, Galán, María. 2024. Identification of new therapeutic targets related to endoplasmic reticulum stress and mitochondrial dysfunction to reduce the risk of rupture in degenerative ascending aortic aneurysm. In Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis, , . doi:10.1016/j.arteri.2024.09.002. https://pubmed.ncbi.nlm.nih.gov/39424523/
6. Maruszczak, Klaudia K, Draczkowski, Piotr, Wnorowski, Artur, Chacinska, Agnieszka. 2024. Structure prediction analysis of human core TIM23 complex reveals conservation of the protein translocation mechanism. In FEBS open bio, 14, 1656-1667. doi:10.1002/2211-5463.13840. https://pubmed.ncbi.nlm.nih.gov/38837610/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest