C57BL/6JCya-Nup210em1flox/Cya
Common Name:
Nup210-flox
Product ID:
S-CKO-18819
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Nup210-flox
Strain ID
CKOCMP-54563-Nup210-B6J-VB
Gene Name
Product ID
S-CKO-18819
Gene Alias
9830001L10; Pom210; gp190; gp210
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Nup210em1flox/Cya mice (Catalog S-CKO-18819) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032179
NCBI RefSeq
NM_018815
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Nup210, also known as Nucleoporin 210 or gp210, is a component of the nuclear pore complex (NPC) in eukaryotic cells. The NPC is crucial for regulating nucleoplasmic transport, transcription, and genomic integrity [1]. Nup210's functions are associated with these processes, and its study in genetic models like KO mouse models has provided insights into its role in various biological processes and diseases.
In KO mouse models, ablation of Nup210 leads to delayed muscle repair after injury, an increased percentage of centrally nucleated fibers, abnormal fiber type distribution with age, and reduced muscle endurance during voluntary running, indicating its importance in maintaining skeletal muscle integrity and function [2]. In breast cancer mouse models, Nup210 depletion suppresses lung metastasis as it acts as a metastasis susceptibility gene and cellular mechanosensor [3]. In addition, Nup210 knockout mice show altered CD4/CD8 T cell ratios, suggesting a T cell-intrinsic function in peripheral T cell homeostasis [4].
In conclusion, Nup210 plays essential roles in multiple biological processes, including muscle repair, muscle integrity maintenance, T cell homeostasis, and cancer metastasis. Studies using KO mouse models have been crucial in revealing these functions, providing valuable insights into its role in related disease areas such as muscle-related disorders and cancer.
References:
1. Han, Fangyi, Fan, Xingdi, Hu, Minxuan, Ye, Yaping, Jiao, Hongli. 2024. Nup210 Promotes Colorectal Cancer Progression by Regulating Nuclear Plasma Transport. In Laboratory investigation; a journal of technical methods and pathology, 104, 102149. doi:10.1016/j.labinv.2024.102149. https://pubmed.ncbi.nlm.nih.gov/39393532/
2. Sakuma, Stephen, Zhu, Ethan Ys, Raices, Marcela, Murad, Rabi, D'Angelo, Maximiliano A. 2021. Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity. In Life science alliance, 5, . doi:10.26508/lsa.202101216. https://pubmed.ncbi.nlm.nih.gov/34911810/
3. Amin, Ruhul, Shukla, Anjali, Zhu, Jacqueline Jufen, Ruan, Yijun, Hunter, Kent W. 2021. Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. In Nature communications, 12, 7216. doi:10.1038/s41467-021-27451-w. https://pubmed.ncbi.nlm.nih.gov/34903738/
4. van Nieuwenhuijze, Annemarie, Burton, Oliver, Lemaitre, Pierre, Humblet-Baron, Stephanie, Liston, Adrian. 2018. Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations. In Frontiers in immunology, 9, 2234. doi:10.3389/fimmu.2018.02234. https://pubmed.ncbi.nlm.nih.gov/30323813/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen