C57BL/6JCya-H1f1em1flox/Cya
Common Name:
H1f1-flox
Product ID:
S-CKO-18942
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
H1f1-flox
Strain ID
CKOCMP-80838-H1f1-B6J-VA
Gene Name
Product ID
S-CKO-18942
Gene Alias
H1-1; H1.1; H1a; H1var3; Hist1h1a
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-H1f1em1flox/Cya mice (Catalog S-CKO-18942) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000055770
NCBI RefSeq
NM_030609
Target Region
Exon 1
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
H1f1 is a gene that is involved in multiple biological processes. Its role in signaling pathways is indicated, as the H1F1 signaling was aberrantly regulated in the endometrium of patients with intrauterine adhesion (IUA), suggesting its importance in this disease-related biological context [1].
In a study on Trichilia silvatica extracts, the leaf extract at 250 μg/ml and the stem extract at 100 μg/mL upregulated the expression of H1F1. This upregulation may be related to the plant extract's anti-inflammatory properties, potentially enhancing tissue oxygenation and nutrient supply through increased expression of H1F1 [2].
In conclusion, H1f1 is involved in signaling pathways, as seen in IUA, and its expression can be modulated by certain plant extracts. Understanding H1f1 may provide insights into the mechanisms of IUA and the anti-inflammatory effects of Trichilia silvatica extracts, which could potentially contribute to the development of new therapeutic strategies for related diseases.
References：
1. Gao, Linzhi, Liang, Enming, Zhang, Dong, Wang, Xiaoyu, Shen, Yuan. 2023. Epigenetic alternations and targeted therapy in intrauterine adhesion: A comparative study. In Genomics, 115, 110673. doi:10.1016/j.ygeno.2023.110673. https://pubmed.ncbi.nlm.nih.gov/37385390/
2. Silveira, Leonardo Lopes, Santos Dias, Manoela Maciel Dos, Pelinsari, Silvânia Mól, Almeida, Vera Lúcia de, Gonçalves, Reggiani Vilela. 2025. Trichilia silvatica extracts modulate the oxinflammatory response: an in vitro analysis. In Journal of ethnopharmacology, , 119973. doi:10.1016/j.jep.2025.119973. https://pubmed.ncbi.nlm.nih.gov/40368256/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen