C57BL/6JCya-Lsrem1flox/Cya
Common Name
Lsr-flox
Product ID
S-CKO-19014
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-54135-Lsr-B6J-VB
When using this mouse strain in a publication, please cite “Lsr-flox Mouse (Catalog S-CKO-19014) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Lsr-flox
Strain ID
CKOCMP-54135-Lsr-B6J-VB
Gene Name
Product ID
S-CKO-19014
Gene Alias
ILDR3, Lisch7
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000001279
NCBI RefSeq
NM_017405
Target Region
Exon 1~2
Size of Effective Region
~1.9 kb
Overview of Gene Research
Lsr, also known as Lipolysis-stimulated lipoprotein receptor, is a multi-functional protein. It is essential for the assembly of epithelial tricellular tight junctions and hepatic clearance of lipoproteins. It is also involved in various signaling pathways such as Hippo/YAP, HDAC, AMPK, and affects cell metabolism [1,2].
Using multiple conditional deletion mouse models, it was found that Lsr elimination in intestinal stem cells leads to the disappearance of Paneth cells without influencing the differentiation of other cell lineages. Lsr deficiency increases the abundance of YAP by modulating its phosphorylation and proteasomal degradation. Lsr protects against necrotizing enterocolitis through enhancing Paneth cell differentiation in the small-intestinal epithelium [1].
In conclusion, Lsr plays crucial roles in maintaining epithelial barriers, cell proliferation, differentiation, and metabolism. The study of Lsr using KO/CKO mouse models has revealed its significance in intestinal epithelium homeostasis and necrotizing enterocolitis, providing potential therapeutic targets for this disease.
References：
1. An, Yanan, Wang, Chao, Fan, Baozhen, Zhao, Shengtian, Gong, Yongfeng. 2023. LSR targets YAP to modulate intestinal Paneth cell differentiation. In Cell reports, 42, 113118. doi:10.1016/j.celrep.2023.113118. https://pubmed.ncbi.nlm.nih.gov/37703178/
2. Shimada, Hiroshi, Kohno, Takayuki, Konno, Takumi, Saito, Tsuyoshi, Kojima, Takashi. 2021. The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma. In Cancers, 13, . doi:10.3390/cancers13246341. https://pubmed.ncbi.nlm.nih.gov/34944960/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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