C57BL/6JCya-Npdc1em1flox/Cya
Common Name
Npdc1-flox
Product ID
S-CKO-19025
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-18146-Npdc1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Npdc1-flox Mouse (Catalog S-CKO-19025) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Npdc1-flox
Strain ID
CKOCMP-18146-Npdc1-B6J-VA
Gene Name
Product ID
S-CKO-19025
Gene Alias
NPDC-1
Background
C57BL/6JCya
Gene Full Name
neural proliferation, differentiation and control 1
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 2 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000071442
NCBI Transcript ID
NM_008721
Target Region
Exon 3~9
Size of Effective Region
~2.7 kb
Overview of Gene Research
Npdc1, short for neural proliferation differentiation and control 1, is a gene with significant functions in neural cell proliferation and differentiation [4]. It is involved in various biological processes and has potential implications in multiple diseases. Its expression pattern and functions suggest it may play a role in the development of certain secretion glands as well [4].
In colon cancer, Npdc1 expression is significantly correlated with patient prognosis and perineural invasion (PNI) status. High Npdc1 expression may promote tumorigenesis, progression, and chemoresistance, indicating its potential as a predictive marker for PNI status, disease-free survival, and overall survival in colon cancer patients [1].
In the context of retinal progenitor cells (RPCs), miR-762 regulates RPC proliferation and differentiation by targeting Npdc1. Inhibition of Npdc1 by miR-762 positively regulates RPC proliferation and suppresses neuronal differentiation [2]. Arhgef2 deficiency impairs neural differentiation in the cerebral cortex by reducing m6A methylation of Npdc1 mRNA, which in turn inhibits its translation, highlighting the role of Npdc1 in neural differentiation [3].
In summary, Npdc1 plays crucial roles in neural-related biological processes such as neural cell proliferation, differentiation, and axon regeneration [2,3,5]. Its abnormal regulation is associated with diseases like colon cancer, potentially influencing tumor development and patient prognosis [1]. The study of Npdc1 using various genetic models has provided valuable insights into its functions and its implications in disease, which may contribute to the development of new diagnostic and therapeutic strategies.
References：
1. Li, Jiannan, Sun, Yao, Cao, Lanqing, Wang, Fang. 2023. Correlation of NPDC1 Expression and Perineural Invasion Status with Clinicopathological Features in Patients with Colon Cancer. In International journal of general medicine, 16, 4549-4563. doi:10.2147/IJGM.S428590. https://pubmed.ncbi.nlm.nih.gov/37822345/
2. Gao, Huiqin, Ni, Ni, Zhang, Dandan, Liu, Yan, Gu, Ping. 2020. miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1. In Cell cycle (Georgetown, Tex.), 19, 1754-1767. doi:10.1080/15384101.2020.1777805. https://pubmed.ncbi.nlm.nih.gov/32544377/
3. Zhou, Pei, Qi, Yifei, Fang, Xiang, Kaindl, Angela M, Hu, Hao. 2021. Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1. In iScience, 24, 102645. doi:10.1016/j.isci.2021.102645. https://pubmed.ncbi.nlm.nih.gov/34142067/
4. Qu, X, Zhang, C, Zhai, Y, Wu, S, He, F. . Characterization and tissue expression of a novel human gene npdc1. In Gene, 264, 37-44. doi:. https://pubmed.ncbi.nlm.nih.gov/11245976/
5. Lin-Moore, Alexander T, Oyeyemi, Motunrayo J, Hammarlund, Marc. 2021. rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans. In PLoS genetics, 17, e1009877. doi:10.1371/journal.pgen.1009877. https://pubmed.ncbi.nlm.nih.gov/34818334/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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