C57BL/6JCya-Btbd17em1flox/Cya
Common Name:
Btbd17-flox
Product ID:
S-CKO-19244
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Btbd17-flox
Strain ID
CKOCMP-72014-Btbd17-B6J-VB
Gene Name
Product ID
S-CKO-19244
Gene Alias
1500005I02Rik; Tango10a
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Btbd17em1flox/Cya mice (Catalog S-CKO-19244) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000000206
NCBI RefSeq
NM_028055
Target Region
Exon 2
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Btbd17, whose functions and common aliases are not detailed in the given reference, may have its role explored through genetic models for functional studies. While its exact function, associated pathways, and overall biological importance are yet to be comprehensively defined, it's evident that research on this gene could potentially shed light on various biological processes.
In a study analyzing the effects of hepatitis B virus X protein (HBx) on H3K9me3 enrichments in hepatoma cells, Btbd17 was among 25 gene promoters whose H3K9me3 enrichments were significantly altered in hepatoma cells transfected with an HBx-expressing plasmid. Specifically, its H3K9me3 enrichment was changed, suggesting a possible link to the cellular pathways influenced by HBx in hepatocellular carcinoma (HCC) [1].
In conclusion, although not fully characterized, Btbd17 may play a role in the context of HCC, as indicated by the alteration of H3K9me3 enrichment on its promoter in the presence of HBx. Studies like these contribute to understanding the complex biological processes in HCC and the potential involvement of Btbd17 in this disease area.
References:
1. Wang, Di-Yi, An, Shu-Hong, Liu, Lei, Zhu, Rong, Wang, Zhao-Jin. . Hepatitis B virus X protein influences enrichment profiles of H3K9me3 on promoter regions in human hepatoma cell lines. In Oncotarget, 7, 84883-84892. doi:10.18632/oncotarget.12751. https://pubmed.ncbi.nlm.nih.gov/27768594/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen