C57BL/6JCya-Csem1flox/Cya
Common Name:
Cs-flox
Product ID:
S-CKO-19467
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Cs-flox
Strain ID
CKOCMP-12974-Cs-B6J-VC
Gene Name
Product ID
S-CKO-19467
Gene Alias
2610511A05Rik; 9030605P22Rik; Ahl4; Cis
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Csem1flox/Cya mice (Catalog S-CKO-19467) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000005826
NCBI RefSeq
NM_026444
Target Region
Exon 5~7
Size of Effective Region
~6.3 kb
Detailed Document
Overview of Gene Research
Cs could refer to the circumsporozoite protein gene in Plasmodium falciparum. The CS protein is a prime malaria vaccine candidate, with immunity to malaria sporozoites in mice mediated mainly by cytotoxic T lymphocytes (CTL) specific for epitopes within the CS protein. In humans, identifying the CTL-recognized epitopes and polymorphisms in the CS protein is crucial for the design of a subunit vaccine [1].
The gene may also be related to chondroitin sulfate, a major glycosaminoglycan. Chondroitin sulfate plays vital roles in various normal physiological and pathological processes, such as anti-oxidation, anti-atherosclerosis, anti-thrombosis, and has insignificant immunogenicity. However, the heterogeneity of natural chondroitin sulfate limits structure-activity relationship studies. Thus, synthesis of well-defined chondroitin sulfate is of great interest for drug development [2].
In conclusion, the Cs-related genes are important in malaria vaccine research and understanding the biological functions and structure-activity relationships of chondroitin sulfate, which may provide new strategies for malaria prevention and drug development related to chondroitin sulfate-associated functions.
References：
1. Doolan, D L, Good, M F. . Plasmodium falciparum CS protein--prime malaria vaccine candidate: definition of the human CTL domain and analysis of its variation. In Memorias do Instituto Oswaldo Cruz, 87 Suppl 3, 241-7. doi:. https://pubmed.ncbi.nlm.nih.gov/1285314/
2. Ji, Yuan, Zhang, Shilin, Qiao, Meng, Zhang, Xing, Huang, He. 2020. Synthesis of structurally defined chondroitin sulfate: Paving the way to the structure-activity relationship studies. In Carbohydrate polymers, 248, 116796. doi:10.1016/j.carbpol.2020.116796. https://pubmed.ncbi.nlm.nih.gov/32919534/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen