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C57BL/6JCya-Larp7em1flox/Cya
Common Name:
Larp7-flox
Product ID:
S-CKO-19591
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Larp7-flox
Strain ID
CKOCMP-28036-Larp7-B6J-VB
Gene Name
Larp7
Product ID
S-CKO-19591
Gene Alias
C330027G06Rik; D3Wsu161e
Background
C57BL/6JCya
NCBI ID
28036
Modification
Conditional knockout
Chromosome
3
Phenotype
MGI:107634
Document
Click here to download >>
Application
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Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Larp7em1flox/Cya mice (Catalog S-CKO-19591) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029588
NCBI RefSeq
NM_138593
Target Region
Exon 9
Size of Effective Region
~0.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Larp7, or La ribonucleoprotein domain family member 7, is a master regulator involved in multiple crucial biological functions. It binds to 7SK RNA as part of the 7SK small nuclear ribonucleoprotein, inhibiting RNA polymerase II transcriptional activity. It also plays roles in RNP assembly, RNA modification, processing, and cellular transport [3]. Larp7 is associated with pathways like the DNA damage response and is vital for processes such as mitochondrial biogenesis, energy production, and maintaining normal cellular function [1]. Genetic models, especially KO and CKO mouse models, have been instrumental in studying its functions.

Global and cardiac-specific Larp7 knockout mice have demonstrated its significance in heart function. Constitutive Larp7 knockout in mice led to impaired mitochondrial biogenesis, myocardial hypoplasia, and mid-gestational lethality. Cardiac-specific inactivation resulted in defective mitochondrial biogenesis, impaired oxidative phosphorylation, elevated oxidative stress, and heart failure by 4 months of age. These defects were linked to reduced SIRT1 stability and deacetylase activity, affecting genes for oxidative phosphorylation and energy metabolism [1]. Deletion of Larp7 in a rodent model also led to senescent cell accumulation and premature aging, revealing its role in cellular senescence [2].

In conclusion, Larp7 is essential for mitochondrial biogenesis, energy production, and cardiac function. Mouse KO/CKO models have revealed its critical role in heart failure pathogenesis, cellular senescence, and related disease areas such as atherosclerosis. Understanding Larp7's functions through these models provides potential targets for therapeutic intervention in heart-related and age-related diseases.

References:
1. Yu, Huijing, Zhang, Fang, Yan, Pengyi, Sun, Kun, Zhang, Bing. 2021. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. In Circulation, 143, 2007-2022. doi:10.1161/CIRCULATIONAHA.120.050812. https://pubmed.ncbi.nlm.nih.gov/33663221/
2. Yan, Pengyi, Li, Zixuan, Xiong, Junhao, Huang, Yu, Zhang, Bing. . LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. In Cell reports, 37, 110038. doi:10.1016/j.celrep.2021.110038. https://pubmed.ncbi.nlm.nih.gov/34818543/
3. Hasler, Daniele, Meister, Gunter, Fischer, Utz. 2020. Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism. In RNA biology, 18, 290-303. doi:10.1080/15476286.2020.1767952. https://pubmed.ncbi.nlm.nih.gov/32401147/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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