C57BL/6JCya-Slc44a1em1/Cya
Common Name:
Slc44a1-KO
Product ID:
S-KO-00105
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Slc44a1-KO
Strain ID
KOCMP-100434-Slc44a1-B6J-VA
Gene Name
Product ID
S-KO-00105
Gene Alias
2210409B22Rik; 4833416H08Rik; CHTL1; CTL1; Cdw92
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc44a1em1/Cya mice (Catalog S-KO-00105) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102911
NCBI RefSeq
NM_133891
Target Region
Exon 6~12
Size of Effective Region
~10.1 kb
Detailed Document
Overview of Gene Research
Slc44a1, also known as choline transporter-like protein 1 (CTL1), is a recently discovered choline transporter. It has an intermediate affinity for choline, with its transport being Na(+)-independent and sensitive to inhibition by hemicholinium-3. Choline is crucial for metabolite synthesis, epigenetic regulation, and is involved in processes like cell membrane integrity, cholinergic neurotransmission, and methylation [1,5].
Some key findings related to Slc44a1 include its association with cognitive improvement in children diagnosed with fetal alcohol spectrum disorder. Genetic polymorphisms in Slc44a1 are associated with performance in cognitive tasks, and certain alleles are related to greater vulnerability to choline deficiency [3]. Also, in papillary glioneuronal tumors (PGNT), the SLC44A1-PRKCA fusion is a characteristic alteration, suggesting it could be a potential biomarker for PGNT [2,4,6].
In conclusion, Slc44a1 is an important choline transporter with implications in cognitive function and in certain tumorigenesis, especially in PGNT. The study of Slc44a1 through genetic polymorphisms and fusion gene analysis has provided insights into its role in these biological processes and disease conditions [2,3,4,6].
References:
1. Michel, Vera, Bakovic, Marica. . The ubiquitous choline transporter SLC44A1. In Central nervous system agents in medicinal chemistry, 12, 70-81. doi:. https://pubmed.ncbi.nlm.nih.gov/22483272/
2. Nagaishi, Masaya, Nobusawa, Sumihito, Matsumura, Nozomi, Yokoo, Hideaki, Nakazato, Yoichi. 2015. SLC44A1-PRKCA fusion in papillary and rosette-forming glioneuronal tumors. In Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 23, 73-75. doi:10.1016/j.jocn.2015.04.021. https://pubmed.ncbi.nlm.nih.gov/26260115/
3. Smith, Susan M, Virdee, Manjot S, Eckerle, Judith K, Zeisel, Steven H, Wozniak, Jeffrey R. . Polymorphisms in SLC44A1 are associated with cognitive improvement in children diagnosed with fetal alcohol spectrum disorder: an exploratory study of oral choline supplementation. In The American journal of clinical nutrition, 114, 617-627. doi:10.1093/ajcn/nqab081. https://pubmed.ncbi.nlm.nih.gov/33876196/
4. Bridge, Julia A, Liu, Xiao-Qiong, Sumegi, Janos, Bowdino, Bradley S, McComb, Rodney D. 2012. Identification of a novel, recurrent SLC44A1-PRKCA fusion in papillary glioneuronal tumor. In Brain pathology (Zurich, Switzerland), 23, 121-8. doi:10.1111/j.1750-3639.2012.00612.x. https://pubmed.ncbi.nlm.nih.gov/22725730/
5. Wortmann, Saskia B, Mayr, Johannes A. 2019. Choline-related-inherited metabolic diseases-A mini review. In Journal of inherited metabolic disease, 42, 237-242. doi:10.1002/jimd.12011. https://pubmed.ncbi.nlm.nih.gov/30681159/
6. Pages, Melanie, Lacroix, Ludovic, Tauziede-Espariat, Arnault, Chretien, Fabrice, Varlet, Pascale. 2015. Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion. In Acta neuropathologica communications, 3, 85. doi:10.1186/s40478-015-0264-5. https://pubmed.ncbi.nlm.nih.gov/26671581/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen