Pom121, or nuclear pore membrane protein 121, is a part of the nuclear pore complex. It is involved in regulating nucleocytoplasmic transport, which is crucial for maintaining normal cellular functions, and participates in various signaling pathways like PI3K/AKT and TGF-β/SMAD [1,3]. Abnormal Pom121 expression has been associated with many diseases, highlighting its biological importance [2]. Genetic models can be valuable in further exploring its functions.

In a POM121fl/fl Lyzm-Cre+ mouse model, higher susceptibility to LPS-induced acute lung injury and more severe tissue inflammation were observed compared to control mice. This indicates that POM121 inhibits the macrophage inflammatory response by repressing the NF-κB signal pathway via inhibition of phosphorylated P65 nuclear accumulation [2].

In conclusion, Pom121 is essential for nucleocytoplasmic transport and is involved in multiple signaling pathways. The POM121 -deficient mouse model has provided insights into its role in macrophage-mediated inflammation, suggesting its potential significance in inflammatory disease research.

References:

1. Kang, Changyuan, Jia, Lizhou, Hao, Lei, Liu, Yang, Zhang, Lingli. 2023. POM121 promotes the proliferation and metastasis of gastric cancer via PI3K/AKT/MYC pathway. In American journal of cancer research, 13, 485-497. doi:. https://pubmed.ncbi.nlm.nih.gov/36895982/

2. Ge, Wenlong, Yue, Yan, Xiong, Sidong. 2019. POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation. In Experimental cell research, 377, 17-23. doi:10.1016/j.yexcr.2019.02.021. https://pubmed.ncbi.nlm.nih.gov/30802453/

3. Guan, Lirong, Zhang, Lingli, Wang, Tengqi, Yan, Huishan, Zhao, Kun. . POM121 promotes proliferation and metastasis in non-small-cell lung cancer through TGF-β/SMAD and PI3K/AKT pathways. In Cancer biomarkers : section A of Disease markers, 32, 293-302. doi:10.3233/CBM-210001. https://pubmed.ncbi.nlm.nih.gov/34151840/