C57BL/6JCya-Pom121em1/Cya
Common Name
Pom121-KO
Product ID
S-KO-00549
Backgroud
C57BL/6JCya
Strain ID
KOCMP-107939-Pom121-B6J-VA
When using this mouse strain in a publication, please cite “Pom121-KO Mouse (Catalog S-KO-00549) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pom121-KO
Strain ID
KOCMP-107939-Pom121-B6J-VA
Gene Name
Product ID
S-KO-00549
Gene Alias
2610027A18Rik, mKIAA0618
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000111171
NCBI RefSeq
NM_148932
Target Region
Exon 4~5
Size of Effective Region
~3.5 kb
Overview of Gene Research
Pom121, or nuclear pore membrane protein 121, is a part of the nuclear pore complex. It is involved in regulating nucleocytoplasmic transport, which is crucial for maintaining normal cellular functions, and participates in various signaling pathways like PI3K/AKT and TGF-β/SMAD [1,3]. Abnormal Pom121 expression has been associated with many diseases, highlighting its biological importance [2]. Genetic models can be valuable in further exploring its functions.
In a POM121fl/fl Lyzm-Cre+ mouse model, higher susceptibility to LPS-induced acute lung injury and more severe tissue inflammation were observed compared to control mice. This indicates that POM121 inhibits the macrophage inflammatory response by repressing the NF-κB signal pathway via inhibition of phosphorylated P65 nuclear accumulation [2].
In conclusion, Pom121 is essential for nucleocytoplasmic transport and is involved in multiple signaling pathways. The POM121 -deficient mouse model has provided insights into its role in macrophage-mediated inflammation, suggesting its potential significance in inflammatory disease research.
References:
1. Kang, Changyuan, Jia, Lizhou, Hao, Lei, Liu, Yang, Zhang, Lingli. 2023. POM121 promotes the proliferation and metastasis of gastric cancer via PI3K/AKT/MYC pathway. In American journal of cancer research, 13, 485-497. doi:. https://pubmed.ncbi.nlm.nih.gov/36895982/
2. Ge, Wenlong, Yue, Yan, Xiong, Sidong. 2019. POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation. In Experimental cell research, 377, 17-23. doi:10.1016/j.yexcr.2019.02.021. https://pubmed.ncbi.nlm.nih.gov/30802453/
3. Guan, Lirong, Zhang, Lingli, Wang, Tengqi, Yan, Huishan, Zhao, Kun. . POM121 promotes proliferation and metastasis in non-small-cell lung cancer through TGF-β/SMAD and PI3K/AKT pathways. In Cancer biomarkers : section A of Disease markers, 32, 293-302. doi:10.3233/CBM-210001. https://pubmed.ncbi.nlm.nih.gov/34151840/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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