C57BL/6NCya-C7em1/Cya
Common Name
C7-KO
Product ID
S-KO-00717
Backgroud
C57BL/6NCya
Strain ID
KOCMP-109828-C7-B6N-VA
When using this mouse strain in a publication, please cite “C7-KO Mouse (Catalog S-KO-00717) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
C7-KO
Strain ID
KOCMP-109828-C7-B6N-VA
Gene Name
Product ID
S-KO-00717
Gene Alias
Gm1238, A530026G17
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000110689
NCBI RefSeq
NM_001243837
Target Region
Exon 2~4
Size of Effective Region
~9.9 kb
Overview of Gene Research
C7, or complement component 7, is an essential part of the complement system within innate immunity. It is crucial for the assembly of the membrane attack complex (MAC), which is a key defense mechanism against invading pathogens [1]. The complement system, in which C7 is involved, plays vital roles in host defense and homeostasis [1].
In a study on prostate cancer, C7 was found to be specifically expressed by stromal cells in both mouse and human prostates. Its expression level is inversely correlated with clinical outcomes in prostate cancer. Androgen signaling positively regulates C7 in mouse prostate stromal cells. Increasing C7 expression in allografts suppresses tumor growth in vivo, while C7 haploinsufficiency promotes tumor growth in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model, indicating its tumor-suppressive role [2].
In conclusion, C7 is essential for the formation of the MAC in the complement system, contributing to host defense. In prostate cancer, model-based research using mouse models has shown that C7 can suppress tumor growth, highlighting its potential significance in cancer-related disease areas.
References:
1. Massri, Mariam, Toonen, Erik J M, Sarg, Bettina, Prohászka, Zoltán, Würzner, Reinhard. 2024. Complement C7 and clusterin form a complex in circulation. In Frontiers in immunology, 15, 1330095. doi:10.3389/fimmu.2024.1330095. https://pubmed.ncbi.nlm.nih.gov/38333209/
2. Zhou, Zhicheng, Jia, Deyong, Kwon, Ohjoon, Lee, John K, Xin, Li. 2023. Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth. In Oncogene, 42, 2428-2438. doi:10.1038/s41388-023-02759-7. https://pubmed.ncbi.nlm.nih.gov/37400528/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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