The gene Pgd, short for Phosphogluconate Dehydrogenase, is involved in the pentose phosphate pathway, an important metabolic pathway that provides ribose-5-phosphate for nucleotide synthesis and NADPH for redox reactions. NADPH is crucial for many cellular processes such as antioxidant defense and fatty acid synthesis. This pathway and the function of Pgd are of great biological importance in maintaining cellular homeostasis and supporting cell growth and proliferation [1].

No information regarding KO/CKO mouse models or loss-of-function experiments was found in the provided references.

In summary, Pgd plays an essential role in the pentose phosphate pathway, which is vital for nucleotide synthesis and redox-related cellular functions. Since no relevant mouse model-based disease findings were in the references, its role in diseases based on such models remains undiscussed from this set of references. However, understanding Pgd's function is fundamental for comprehending related metabolic and cellular processes.

References:

1. Uehara, Yoshio. . [PGD(2)/L-PGDS system in hypertension and renal injury]. In Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 123, 23-33. doi:. https://pubmed.ncbi.nlm.nih.gov/14695455/