C57BL/6JCya-Chrna7em1/Cya
Common Name:
Chrna7-KO
Product ID:
S-KO-00856
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Chrna7-KO
Strain ID
KOCMP-11441-Chrna7-B6J-VA
Gene Name
Product ID
S-KO-00856
Gene Alias
Acra7; alpha7; nAchR
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Chrna7em1/Cya mice (Catalog S-KO-00856) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032738
NCBI RefSeq
NM_007390.3
Target Region
Exon 4
Size of Effective Region
~110 bp
Detailed Document
Overview of Gene Research
Chrna7, the gene encoding the α7 neuronal nicotinic acetylcholine receptor, is ubiquitously expressed in both the central nervous system and the periphery. It is involved in cholinergic neurotransmission and is linked to multiple disorders with cognitive deficits such as schizophrenia, bipolar disorder, ADHD, epilepsy, Alzheimer's disease, and Rett syndrome [1].
Chrna7 -deficient mice have been studied to understand its role. One study found that Chrna7 knockout mice display depression-like behaviors, and splenic nerve denervation can attenuate these behaviors via the spleen-gut-brain axis [2]. However, another study indicated that Chrna7-deficient mice do not show consistent neuropsychiatric and behavioral phenotypes with decreased Chrna7 copy number [3].
In conclusion, Chrna7 is crucial for cholinergic neurotransmission and is associated with multiple neuropsychiatric disorders. Research on Chrna7 knockout mouse models has provided some insights into its role in depression-like behaviors and the potential spleen-gut-brain axis involvement, but there are also findings suggesting a lack of consistent phenotypes related to decreased gene copy number.
References:
1. Sinkus, Melissa L, Graw, Sharon, Freedman, Robert, Lester, Henry A, Leonard, Sherry. 2015. The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function. In Neuropharmacology, 96, 274-88. doi:10.1016/j.neuropharm.2015.02.006. https://pubmed.ncbi.nlm.nih.gov/25701707/
2. Yang, Yong, Eguchi, Akifumi, Mori, Chisato, Hashimoto, Kenji. 2024. Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis. In Journal of affective disorders, 362, 114-125. doi:10.1016/j.jad.2024.06.091. https://pubmed.ncbi.nlm.nih.gov/38944290/
3. Yin, Jiani, Chen, Wu, Yang, Hongxing, Xue, Mingshan, Schaaf, Christian P. 2017. Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes. In Scientific reports, 7, 39941. doi:10.1038/srep39941. https://pubmed.ncbi.nlm.nih.gov/28045139/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen