Apoa2, short for apolipoprotein A-II, is a significant protein involved in lipid metabolism. It is associated with high-density lipoprotein (HDL) and plays a role in promoting cellular cholesterol efflux, which is crucial for maintaining healthy lipid profiles and may contribute to cardiovascular disease protection [2].

Research has identified Apoa2 as a target biomarker for molecular hydrogen therapy in sepsis-related lung injury, showing a protective, causal relationship with sepsis [1]. In lipid metabolism, Apoa2 can increase the cholesterol efflux capacity of plasma HDL by displacing the C-terminus of APOA1, suggesting it could be a novel therapeutic target for enhancing cholesterol efflux [2]. Additionally, Apoa2-256T > C polymorphism interacts with dietary indexes affecting biochemical markers in type 2 diabetic patients, indicating its role in diabetes-related metabolic processes [3].

In summary, Apoa2 is essential in lipid-related biological functions. Studies on Apoa2 have implications in multiple disease areas, such as sepsis, cardiovascular diseases, and diabetes, highlighting its significance in understanding disease mechanisms and potentially developing new therapies.

References:

1. Wang, Yuanlin, Fan, Yan, Jiang, Yi, Xie, Keliang, Yu, Yonghao. 2023. APOA2: New Target for Molecular Hydrogen Therapy in Sepsis-Related Lung Injury Based on Proteomic and Genomic Analysis. In International journal of molecular sciences, 24, . doi:10.3390/ijms241411325. https://pubmed.ncbi.nlm.nih.gov/37511084/

2. Sarkar, Snigdha, Morris, Jamie, You, Youngki, Davidson, W Sean, Melchior, John T. 2024. APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1. In Journal of lipid research, 65, 100686. doi:10.1016/j.jlr.2024.100686. https://pubmed.ncbi.nlm.nih.gov/39490930/

3. Esmaeily, Zahra, Sotoudeh, Gity, Rafiee, Masoumeh, Koohdani, Fariba. 2021. ApoA2-256T > C polymorphism interacts with Healthy Eating Index, Dietary Quality Index-International and Dietary Phytochemical Index to affect biochemical markers among type 2 diabetic patients. In The British journal of nutrition, 127, 1343-1351. doi:10.1017/S0007114521002348. https://pubmed.ncbi.nlm.nih.gov/34167597/