C57BL/6NCya-Camk2gem1/Cya
Common Name
Camk2g-KO
Product ID
S-KO-01311
Backgroud
C57BL/6NCya
Strain ID
KOCMP-12325-Camk2g-B6N-VB
When using this mouse strain in a publication, please cite “Camk2g-KO Mouse (Catalog S-KO-01311) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Camk2g-KO
Strain ID
KOCMP-12325-Camk2g-B6N-VB
Gene Name
Product ID
S-KO-01311
Gene Alias
Camkg
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000071816
NCBI RefSeq
NM_178597
Target Region
Exon 6~9
Size of Effective Region
~2.3 kb
Overview of Gene Research
Camk2g, encoding the gamma subunit of calcium/calmodulin-dependent protein kinase 2, is expressed throughout the brain and is involved in multiple biological processes. It functions in the MPL-JAK2 signaling pathway and is associated with neurodevelopmental processes. Genetic models, such as knockout mouse models, are valuable for studying its function [1,2].
In a myelofibrosis (MF) study, Camk2g was identified as a potential therapeutic target. In MF model cells and mice, inhibition of Camk2g was effective against both JAK2 inhibitor-sensitive and resistant cells. Berbamine, a Camk2g inhibitor, prolonged survival and reduced disease phenotypes in an MF mouse model [1]. In Camk2g knockout mice, the loss of Camk2g affected motor function and innate behaviors associated with neurodevelopment, while having a minimal impact on cognitive behavior [2]. In neuroblastoma cells, knockdown of Camk2g inhibited neuronal differentiation and promoted migration [3].
In conclusion, Camk2g plays important roles in both hematological and neurological processes. Its inhibition shows potential as a novel therapeutic strategy for myelofibrosis. The study of Camk2g using knockout mouse models has provided insights into its functions in neurodevelopment and disease-related biological processes, highlighting its significance in understanding these areas.
References:
1. Miyauchi, Masashi, Sasaki, Ken, Kagoya, Yuki, Mizuno, Hideaki, Kurokawa, Mineo. . CAMK2G is identified as a novel therapeutic target for myelofibrosis. In Blood advances, 6, 1585-1597. doi:10.1182/bloodadvances.2020003303. https://pubmed.ncbi.nlm.nih.gov/34521112/
2. Rigter, Pomme M F, de Konink, Charlotte, van Woerden, Geeske M. 2023. Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior. In Frontiers in neuroscience, 16, 1086994. doi:10.3389/fnins.2022.1086994. https://pubmed.ncbi.nlm.nih.gov/36685241/
3. Ma, Yujie, He, Cong, Lin, Weihong, Jia, Deshui, Li, Kai. 2024. CAMK2G Promotes Neuronal Differentiation and Inhibits Migration in Neuroblastoma. In Journal of pediatric surgery, 60, 161679. doi:10.1016/j.jpedsurg.2024.08.019. https://pubmed.ncbi.nlm.nih.gov/39266386/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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