Camk2g, encoding the gamma subunit of calcium/calmodulin-dependent protein kinase 2, is expressed throughout the brain and is involved in multiple biological processes. It functions in the MPL-JAK2 signaling pathway and is associated with neurodevelopmental processes. Genetic models, such as knockout mouse models, are valuable for studying its function [1,2].

In a myelofibrosis (MF) study, Camk2g was identified as a potential therapeutic target. In MF model cells and mice, inhibition of Camk2g was effective against both JAK2 inhibitor-sensitive and resistant cells. Berbamine, a Camk2g inhibitor, prolonged survival and reduced disease phenotypes in an MF mouse model [1]. In Camk2g knockout mice, the loss of Camk2g affected motor function and innate behaviors associated with neurodevelopment, while having a minimal impact on cognitive behavior [2]. In neuroblastoma cells, knockdown of Camk2g inhibited neuronal differentiation and promoted migration [3].

In conclusion, Camk2g plays important roles in both hematological and neurological processes. Its inhibition shows potential as a novel therapeutic strategy for myelofibrosis. The study of Camk2g using knockout mouse models has provided insights into its functions in neurodevelopment and disease-related biological processes, highlighting its significance in understanding these areas.

References:

1. Miyauchi, Masashi, Sasaki, Ken, Kagoya, Yuki, Mizuno, Hideaki, Kurokawa, Mineo. . CAMK2G is identified as a novel therapeutic target for myelofibrosis. In Blood advances, 6, 1585-1597. doi:10.1182/bloodadvances.2020003303. https://pubmed.ncbi.nlm.nih.gov/34521112/

2. Rigter, Pomme M F, de Konink, Charlotte, van Woerden, Geeske M. 2023. Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior. In Frontiers in neuroscience, 16, 1086994. doi:10.3389/fnins.2022.1086994. https://pubmed.ncbi.nlm.nih.gov/36685241/

3. Ma, Yujie, He, Cong, Lin, Weihong, Jia, Deshui, Li, Kai. 2024. CAMK2G Promotes Neuronal Differentiation and Inhibits Migration in Neuroblastoma. In Journal of pediatric surgery, 60, 161679. doi:10.1016/j.jpedsurg.2024.08.019. https://pubmed.ncbi.nlm.nih.gov/39266386/