C57BL/6NCya-Compem1/Cya
Common Name:
Comp-KO
Product ID:
S-KO-01592
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Comp-KO
Strain ID
KOCMP-12845-Comp-B6N-VA
Gene Name
Product ID
S-KO-01592
Gene Alias
TSP5
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Compem1/Cya mice (Catalog S-KO-01592) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000003659
NCBI RefSeq
NM_016685
Target Region
Exon 2~9
Size of Effective Region
~2.9 kb
Detailed Document
Overview of Gene Research
COMP, also known as cartilage oligomeric matrix protein, is an extracellular matrix (ECM) glycoprotein. It is critical for collagen assembly and ECM stability, playing a role in processes like bridging different ECM structures and assisting collagen secretion [4,5]. It has been associated with multiple fibrotic conditions and is involved in pathways such as TGF-β signaling [2].
In pancreatic fibrosis, COMP is up-regulated in fibrotic tissues of chronic pancreatitis (CP) patients. Knockdown of COMP in human pancreatic stellate cells (HPSCs) inhibits their proliferation and migration, while recombinant human COMP (rCOMP) promotes HPSCs activation through the CD36-ERK/AKT signaling pathway, suggesting COMP may be a potential therapeutic target for CP [1]. In atrial fibrillation, COMP knockdown inhibits the activation of the TGF-β pathway in AF cells, and COMP can improve Ang-II-induced AF via the TGF-β signaling pathway [2]. In lung transplantation, higher COMP serum levels early after transplantation are associated with the development of restrictive allograft syndrome (RAS), indicating it could be a biomarker for RAS [3]. In pseudoachondroplasia, mutations in COMP cause abnormal chondrocyte function due to protein misfolding and retention in the endoplasmic reticulum [4].
In conclusion, COMP has essential functions in maintaining ECM integrity and is involved in multiple disease-related processes. Studies, especially those using knockdown approaches, have revealed its role in fibrosis-related diseases like pancreatic fibrosis, atrial fibrillation, and RAS after lung transplantation, as well as in skeletal disorders such as pseudoachondroplasia. These findings contribute to understanding disease mechanisms and potentially developing new therapeutic strategies.
References:
1. Wang, Yi, Li, Hai-Tao, Liu, Gang, Wang, Wen, Zeng, Xiang-Peng. 2024. COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways. In Cellular signalling, 118, 111135. doi:10.1016/j.cellsig.2024.111135. https://pubmed.ncbi.nlm.nih.gov/38479555/
2. Cai, XiaoBi, Li, Mingliang, Zhong, Ying, Yang, Wenkun, Liang, Zhu. 2023. COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-β Signaling Pathway. In Cardiovascular toxicology, 23, 305-316. doi:10.1007/s12012-023-09799-1. https://pubmed.ncbi.nlm.nih.gov/37584842/
3. Novo, Mirza, Westin, Johan, Andersson, Lars-Magnus, Nordén, Rickard, Magnusson, Jasper M. 2021. COMP: A Potential Early Biomarker of RAS After Lung Transplantation. In Transplantation direct, 7, e730. doi:10.1097/TXD.0000000000001189. https://pubmed.ncbi.nlm.nih.gov/34291152/
4. Posey, Karen L, Hayes, Elizabeth, Haynes, Richard, Hecht, Jacqueline T. . Role of TSP-5/COMP in pseudoachondroplasia. In The international journal of biochemistry & cell biology, 36, 1005-12. doi:. https://pubmed.ncbi.nlm.nih.gov/15094116/
5. Schulz, Jan-Niklas, Nüchel, Julian, Niehoff, Anja, Zaucke, Frank, Eckes, Beate. 2016. COMP-assisted collagen secretion--a novel intracellular function required for fibrosis. In Journal of cell science, 129, 706-16. doi:10.1242/jcs.180216. https://pubmed.ncbi.nlm.nih.gov/26746240/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen