C57BL/6NCya-Dyrk1bem1/Cya
Common Name
Dyrk1b-KO
Product ID
S-KO-01823
Backgroud
C57BL/6NCya
Strain ID
KOCMP-13549-Dyrk1b-B6N-VA
When using this mouse strain in a publication, please cite “Dyrk1b-KO Mouse (Catalog S-KO-01823) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Dyrk1b-KO
Strain ID
KOCMP-13549-Dyrk1b-B6N-VA
Gene Name
Product ID
S-KO-01823
Gene Alias
Mirk
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000172467
NCBI RefSeq
NM_001271370
Target Region
Exon 1~11
Size of Effective Region
~7.0 kb
Overview of Gene Research
DYRK1B, also known as Mirk, is a serine/threonine kinase activated by intramolecular tyrosine phosphorylation. It is involved in multiple biological processes, such as skeletal muscle differentiation, where it blocks cycling myoblasts in the G0 quiescent state, and in the regulation of ventral spinal cord development via the Shh pathway. It also participates in pathways related to mitochondrial bioenergetics, autophagy, and lipid metabolism [3,4]. Genetic models like transgenic and knockout mice have been crucial for studying DYRK1B's functions [1].
In knockout mouse models, deletion of DYRK1B mitigated transverse aortic constriction-induced cardiac hypertrophy and heart failure, suggesting its role in the progression of these heart-related conditions. The mechanism involves DYRK1B's positive association with impaired mitochondrial bioenergetics by binding with STAT3, increasing its phosphorylation and nuclear accumulation, and downregulating PGC-1α [1]. In pancreatic cancer, genetic ablation of DYRK1B in mouse models strongly attracted tumoricidal macrophages, downregulated the phagocytosis checkpoint CD24 on cancer cells, and inhibited tumor cell expansion [2].
In conclusion, DYRK1B plays essential roles in various biological processes and disease conditions. Model-based research, especially DYRK1B knockout mouse models, has revealed its significant contributions to heart failure and pancreatic cancer, providing potential therapeutic targets for these diseases.
References:
1. Zhuang, Lingfang, Jia, Kangni, Chen, Chen, Chen, Kang, Yan, Xiaoxiang. 2022. DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics. In Circulation, 145, 829-846. doi:10.1161/CIRCULATIONAHA.121.055727. https://pubmed.ncbi.nlm.nih.gov/35235343/
2. Brichkina, Anna, Ems, Miriam, Suezov, Roman, Gress, Thomas M, Lauth, Matthias. 2024. DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer. In Gut, 73, 1684-1701. doi:10.1136/gutjnl-2023-331854. https://pubmed.ncbi.nlm.nih.gov/38834297/
3. Friedman, Eileen. . Mirk/Dyrk1B in cancer. In Journal of cellular biochemistry, 102, 274-9. doi:. https://pubmed.ncbi.nlm.nih.gov/17583556/
4. Kokkorakis, N, Douka, K, Nalmpanti, A, Matsas, R, Gaitanou, M. 2024. Mirk/Dyrk1B controls ventral spinal cord development via Shh pathway. In Cellular and molecular life sciences : CMLS, 81, 70. doi:10.1007/s00018-023-05097-9. https://pubmed.ncbi.nlm.nih.gov/38294527/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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