C57BL/6JCya-Il18r1em1/Cya
Common Name
Il18r1-KO
Product ID
S-KO-02640
Backgroud
C57BL/6JCya
Strain ID
KOCMP-16182-Il18r1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Il18r1-KO Mouse (Catalog S-KO-02640) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Il18r1-KO
Strain ID
KOCMP-16182-Il18r1-B6J-VA
Gene Name
Product ID
S-KO-02640
Gene Alias
Il1rrp, Il18ralpha
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000108044
NCBI RefSeq
NM_008365
Target Region
Exon 2~11
Size of Effective Region
~29.1 kb
Overview of Gene Research
Il18r1, the interleukin 18 receptor 1, is a key component of the IL-18 receptor complex. IL-18, a cytokine of the IL-1 superfamily, exerts its effects via this receptor complex. The IL-18R complex activates signaling pathways such as NF-κB, which is involved in numerous biological processes including innate and acquired immune responses [2,4].
In mouse models, IL-18 receptor-deficient mice had reduced liver fibrosis in a model of fibrosis induced by HSC-specific NLRP3 overactivation. This indicates that Il18r1-mediated IL-18 signaling promotes the activation of hepatic stellate cells, contributing to liver fibrosis [3]. Also, in lung squamous cell carcinoma, overexpression of Il18r1 in cell experiments inhibited the proliferation, migration, and invasion of LUSC cells, suggesting its tumor-suppressive role [1].
In conclusion, Il18r1 is crucial in immune-related signaling pathways. Mouse models have revealed its significant role in liver fibrosis and lung squamous cell carcinoma, highlighting its potential as a therapeutic target in these disease areas.
References:
1. Guo, Qiang, Wu, Chuang-Yan, Jiang, Ni, Liu, Hua-Song, Wang, Si-Hua. 2022. Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma. In Frontiers in immunology, 13, 986447. doi:10.3389/fimmu.2022.986447. https://pubmed.ncbi.nlm.nih.gov/36544782/
2. Gracie, J Alastair, Robertson, Susan E, McInnes, Iain B. . Interleukin-18. In Journal of leukocyte biology, 73, 213-24. doi:. https://pubmed.ncbi.nlm.nih.gov/12554798/
3. Knorr, Jana, Kaufmann, Benedikt, Inzaugarat, Maria Eugenia, Feldstein, Ariel E, Wree, Alexander. 2022. Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. In Hepatology (Baltimore, Md.), 77, 1968-1982. doi:10.1002/hep.32776. https://pubmed.ncbi.nlm.nih.gov/36059147/
4. Dinarello, C A. . Interleukin-18. In Methods (San Diego, Calif.), 19, 121-32. doi:. https://pubmed.ncbi.nlm.nih.gov/10525448/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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