C57BL/6JCya-Clec10aem1/Cya
Common Name
Clec10a-KO
Product ID
S-KO-03190
Backgroud
C57BL/6JCya
Strain ID
KOCMP-17312-Clec10a-B6J-VA
When using this mouse strain in a publication, please cite “Clec10a-KO Mouse (Catalog S-KO-03190) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Clec10a-KO
Strain ID
KOCMP-17312-Clec10a-B6J-VA
Gene Name
Product ID
S-KO-03190
Gene Alias
Mgl, Mgl1, CD301a, M-ASGP-BP-1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000000327
NCBI RefSeq
NM_001204252
Target Region
Exon 2~10
Size of Effective Region
~4.8 kb
Overview of Gene Research
Clec10a, also known as C-type lectin domain family 10 member A, CD301, or macrophage galactose-type lectin (MGL), is a C-type lectin receptor. It contains a carbohydrate-recognition domain specific for N-acetylgalactosamine (GalNAc) and is involved in various immune responses, including the initiation of TH1, TH2, and TH17 immune responses, and induction of tolerance in naïve T cells [2]. It also plays a role in maintaining skin homeostasis [1].
NC/Nga mice carry a stop-gain mutation in Clec10a. Repair of this mutation using the CRISPR-Cas9 system, as well as Clec10a -/- mice on the C57BL/6J background, demonstrated that Clec10a expressed on skin macrophages inhibits house dust mite (HDM)-induced Toll-like receptor 4 (TLR4)-mediated inflammatory cytokine production, and its mutation or deficiency leads to exacerbated HDM-induced dermatitis [1].
In conclusion, Clec10a is crucial for regulating immune responses, especially in maintaining skin homeostasis against inflammation associated with HDM-induced dermatitis. Gene knockout mouse models have been instrumental in revealing its role in this specific disease area, highlighting its potential as a therapeutic target for related skin allergic diseases [1].
References:
1. Kanemaru, Kazumasa, Noguchi, Emiko, Tahara-Hanaoka, Satoko, Fujisawa, Yasuhiro, Nakamura, Yoshiyuki. . Clec10a regulates mite-induced dermatitis. In Science immunology, 4, . doi:10.1126/sciimmunol.aax6908. https://pubmed.ncbi.nlm.nih.gov/31811054/
2. Hoober, J Kenneth. 2020. ASGR1 and Its Enigmatic Relative, CLEC10A. In International journal of molecular sciences, 21, . doi:10.3390/ijms21144818. https://pubmed.ncbi.nlm.nih.gov/32650396/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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