C57BL/6JCya-Klf11em1/Cya
Common Name
Klf11-KO
Product ID
S-KO-04030
Backgroud
C57BL/6JCya
Strain ID
KOCMP-194655-Klf11-B6J-VA
When using this mouse strain in a publication, please cite “Klf11-KO Mouse (Catalog S-KO-04030) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Klf11-KO
Strain ID
KOCMP-194655-Klf11-B6J-VA
Gene Name
Product ID
S-KO-04030
Gene Alias
9830142A17, D12Ertd427e, Tieg2, Tieg2b, Tieg3
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 12
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000020982
NCBI RefSeq
NM_178357
Target Region
Exon 1~4
Size of Effective Region
~11.5 kb
Overview of Gene Research
Klf11, also known as Krüppel-like factor 11, is involved in multiple biological functions and pathways, playing a crucial role in maintaining physiological homeostasis. It has been linked to pathways related to cell death, vascular homeostasis, and tumorigenesis [1,2,3]. Genetic models, such as knockout (KO) mouse models, have been valuable in studying Klf11's functions.
In the context of diseases, Klf11 has diverse roles. In lung adenocarcinoma, overexpression of Klf11 promotes ferroptosis, inhibits cell proliferation, and increases chemosensitivity by suppressing GPX4, while Klf11 knockout has the opposite effects [1]. In diabetic atherosclerosis, EC-specific Klf11 knockout mice show accelerated atherogenesis, indicating that endothelial Klf11 is a protector against this condition [2]. Conventional Klf11 knockout mice are more susceptible to stasis-induced deep vein thrombosis, suggesting Klf11 protects against venous thrombosis by downregulating tissue factor gene transcription [3].
In conclusion, Klf11 is a multifunctional gene involved in various biological processes and disease conditions. Model-based research, especially using Klf11 KO mouse models, has revealed its significant roles in cancer, cardiovascular diseases, and thrombosis, providing potential molecular targets for treating related diseases.
References:
1. Zhao, Guangyin, Liang, Jiaqi, Shan, Guangyao, Zhan, Cheng, Ge, Di. 2023. KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4. In Communications biology, 6, 570. doi:10.1038/s42003-023-04959-z. https://pubmed.ncbi.nlm.nih.gov/37248295/
2. Zhao, Guizhen, Zhao, Yang, Liang, Wenying, Chen, Y Eugene, Zhang, Jifeng. 2024. Endothelial KLF11 is a novel protector against diabetic atherosclerosis. In Cardiovascular diabetology, 23, 381. doi:10.1186/s12933-024-02473-y. https://pubmed.ncbi.nlm.nih.gov/39462409/
3. Liang, Wenying, Lu, Haocheng, Sun, Jinjian, Fan, Yanbo, Zhang, Jifeng. 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. In Thrombosis and haemostasis, 122, 777-788. doi:10.1055/s-0041-1735191. https://pubmed.ncbi.nlm.nih.gov/34428834/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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