There is no information in the provided references directly related to the gene Nhs. Based on the references, we can only assume that Nhs might be confused with other terms. For example, NHS-IL12 is a tumor-targeting immunocytokine consisting of IL-12 fused to a human IgG1 recognizing DNA/histone complexes in tumor necrotic portions, which can enhance immune cell proliferation and activation, reduce suppressive myeloid cells in the tumor microenvironment, and has anti-tumor efficacy in pre-clinical studies [1].

In the context of nanomedicine, inorganic nanoheterostructures (NHS) have potential for diagnostic and therapeutic applications, especially in cancer, but this has no direct relation to a gene [2]. There are also mentions of NHS 111 online which is a health assessment and triage service in the UK, not related to a gene [3].

Since no information about the gene Nhs is available in the references, we cannot discuss its function, associated pathways, or findings from gene knockout models.

In conclusion, without relevant data in the provided references, the function and significance of the gene Nhs remain unknown. Future research would be needed to explore the role of the Nhs gene in biological processes and disease conditions.

References:

1. Greiner, John W, Morillon, Y Maurice, Schlom, Jeffrey. 2021. NHS-IL12, a Tumor-Targeting Immunocytokine. In ImmunoTargets and therapy, 10, 155-169. doi:10.2147/ITT.S306150. https://pubmed.ncbi.nlm.nih.gov/34079772/

2. Quarta, Alessandra, Piccirillo, Clara, Mandriota, Giacomo, Di Corato, Riccardo. 2019. Nanoheterostructures (NHS) and Their Applications in Nanomedicine: Focusing on In Vivo Studies. In Materials (Basel, Switzerland), 12, . doi:10.3390/ma12010139. https://pubmed.ncbi.nlm.nih.gov/30609839/

3. Turnbull, Joanne, MacLellan, Jennifer, Churruca, Kate, Chisambi, Matthew, Pope, Catherine. . A multimethod study of NHS 111 online. In Health and social care delivery research, 11, 1-104. doi:10.3310/YTRR9821. https://pubmed.ncbi.nlm.nih.gov/37464813/